超敏C反应蛋白、同型半胱氨酸浓度与短暂性脑缺血发作中医辨证分型的相关性  

Hypersensitive c-reactive protein and homocysteine concentrations of traditional Chinese medicine with transient ischemic attack

作　　者：李继业[1] 赵智江[2] 

机构地区：[1]保定市第一医院急诊科,河北保定071000 [2]保定市第一医院神经内科,河北保定071000

出　　处：《空军医学杂志》2015年第1期35-36,39,共3页Medical Journal of Air Force

基　　金：国家自然科学基金资助项目(81371286)

摘　　要：目的通过测定血清超敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)及同型半胱氨酸(homocysteine,Hcy)浓度,探讨其与短暂性脑缺血发作(transient ischemic attack,TIA)的相关性,并为中医临床辨证分型提供参考。方法选取180例TIA患者作为观察组和30例健康者作为对照组,将TIA患者按照中医辨证分为5型:肝风内动证、风痰上扰证、痰浊壅闭证、气虚血滞证、脉络瘀阻证。分别对TIA患者和健康对照者血清hs-CRP、Hcy进行检测,并做组间对比。结果观察组血清hs-CRP、Hcy浓度较对照组显著升高(P<0.01),且TIA组各中医证型中,痰浊壅闭证血清hsCRP浓度显著高于其他4型(P<0.05);脉络瘀阻证血清Hcy浓度显著高于其他4型(P<0.05)。结论血清hs-CRP、Hcy浓度的升高不仅是TIA的重要发病原因,而且也反映其严重程度,可作为TIA中医辨证分型的客观指标之一。Object ive To discuss, th rough the deter mination ofser u m hy persensitive c-reactive protein（hs-CR P） and homocysteine（Hcy） concent ration, t ransient ischemic at tack（TI A）, and provide precise basis for clinical t reat ment based on sy nd rome differentiation oft raditional Chinese medicine. Method 180 patients with TI A were chosen as obser vation g roup and 30 cases ofhealthy subjects as cont rol g roup. TI A patients, according to sy nd rome differentiation oft raditional Chi nese medici ne, can be divided i nto 5 t y pes： liver wi nd agit ation, the wi nd phleg m on i nter ference, phleg m t u rbidit y occlusion, debilit y blood st ag nation sy nd rome, and vei n st asis resist ance. Ser u m ofTI A patients and healthy cont rols were used respectively with the hs- detect CR P, Hcy, and compar ison bet ween g roups was made. Results Obser vat ion g roup hs- CR P a nd ser u m Hcy concent rat ion was h ig her t ha n t he cont rol g roup sig nificantly（P〈0.01）, and the TI A g roup ofeach t y pe ofsy nd rome, Phlegm t urbidit y occlusion ser um hs- CR P were sig nificantly higher than other 4 t y pes（P〈0.05）; Vein stasis resistance ser um Hcy concent ration is sig nificantly h ig he r t ha n ot he r 4 t y pe s（P〈0.05）. Conclusion Se r u m h s- t he r ise ofCR P, Hcy conce nt r at ion is not on ly t he impor tant etiolog y ofTI A, but also reflects that its sever it y, hs- CR P ser um, Hcy concent ration can be used as one ofthe objective index TI A oft raditional Chinese medicine.

关 键 词：短暂性脑缺血发作 中医辨证分型 超敏C反应蛋白 同型半胱氨酸 

分 类 号：R743.31[医药卫生—神经病学与精神病学]