大肠恶性肿瘤不同术式治疗效果及对免疫功能的影响  

Application effect of different surgical operation in colorectal cancer and the influence of immune system

作　　者：杨景先 麦建全 陈晓峰 王侦伟 杨卓涛 余颖誉 

机构地区：[1]广东省饶平县人民医院肿瘤外科,饶平515700

出　　处：《中国肿瘤临床与康复》2015年第5期555-557,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨大肠恶性肿瘤不同术式的效果及对免疫功能的影响。方法选取收治的144例大肠恶性肿瘤患者,以数字表法随机分为观察组和对照组,每组72例。观察组患者行腹腔镜大肠癌根治手术,对照组患者行传统的开腹大肠癌根治手术。对比两组患者的手术时间、术中出血量、住院时间和术后并发症等,术前、术后3 d检测两组患者血清Ig A、Ig G、Ig M和C反应蛋白(CRP)水平。结果观察组患者的手术时间为(183.9±27.4)min,术中出血量为(196.3±41.5)ml,住院时间为(10.9±3.1)d,均少于对照组(P<0.05),术后排气时间和并发症总数均优于对照组(P<0.05)。两组患者术后3 d血清Ig A、Ig G和Ig M出现了小幅度下降,CRP含量上升,观察组患者Ig A、Ig G、Ig M和CRP水平较对照组变化幅度更小,差异均有统计学意义(均P<0.05)。结论腹腔镜大肠恶性肿瘤手术对患者的创伤小,对机体的免疫功能影响也更小。Objective To explore the effect of different operation in colorectal cancer and its affect on immune function. Methods Selected 144 cases of eolorectal cancer, which were randomly divided into observation group and control group, with 72 cases in each group. The observation group was given laparo- scopic eolorectal cancer operation, while control group was using the traditional open eoloreetal cancer oper- ation. Operation time, bleeding volume, hospitalization time and postoperative complications were compared between two groups. Serum IgA, IgG, IgM and C reactive protein （CRP） levels were detected preoperative and postoperative 3 d in two groups. Results The operation time of the observation group was （ 183.9 ~ 27.4） min, bleeding volume was （ 196. 3 ＋41.5） ml, hospitalization time was （ 10. 9 ＋3.1 ） d, less than that of the control group （ P 〈 O. 05 ）. Postoperative exhaust time and total number of complications were better in observation group than those of control group （ P 〈 0.05 ）. At postoperative 3 d, serum IgA, IgG and IgM appeared in the small amplitude decreased, while CRP content increased, and IgA, IgG, IgM and CRP level change amplitude is smaller in the observation group than that in the control group, with statisti- cally significant （P 〈 0. 05 ）. Conclusion Patient＇s wound of laparoscopic colorectal cancer operation was small, and has less affect on immune function.

关 键 词：大肠肿瘤 腹腔镜手术 开腹手术 免疫功能 

分 类 号：R735.34[医药卫生—肿瘤]