MicroRNA单核苷酸多态性在肝细胞癌中的研究进展  

Research development of Mirnas single nucleotide polymorphisms in the hepatocellular carcinoma（HCC）

作　　者：汪中海[1] 贺军[1] 陈国栋[1] 

机构地区：[1]南华大学附属第一医院,湖南衡阳421001

出　　处：《医药前沿》2015年第7期15-16,共2页Journal of Frontiers of Medicine

摘　　要：MicroRNA（miRNA）是一类小型非编码RNA，由大约22个核苷酸组成，在转录后水平发挥调控基因表达的功能。越来越多的研究发现，MiRNA在肝癌细胞增殖、分化、凋亡中起着重要作用，其特异性的表达，在肝癌的发生发展过程中扮演着重要的角色。目前学界公认的MicroRNA引起肿瘤发生的机制概括起来如下：（1）RNA聚合酶负责的转录失调有可能是g肝癌肿瘤发生原因；（2） MicroRNA调控网络中相关SNPs改变导致成熟的MicroRNA合成障碍与表达失调；（3）MicroRNA合成通路的关键蛋白界常引起MicroRNA表达改变。因此本文拟对MiRNA单核苷酸多态性在肝细胞癌中的作用作一综述。Micrornas （miRNA） is a kind of small non-coding RNA, is composed of about 22 nucleotides, after the transcription level the function of regulating gene expression. A growing number of studies have found that micrornas in hepatocellular carcinoma cell proliferation, differentiation, apoptosis plays an important role in the expression of its specificity, in the occurrence of cancer of the liver plays an important role in the process of development_ Are recognized as micrornas cause tumorigenesis mechanisms include： （1） the transcription of RNA polymerase is responsible for the disorder have g liver cancer could be the cause; （2） mirna regulation network in the mature mirnas related SNPs changed synthetic barrier and expression disorders; （3） mirna synthesis pathway of key protein bound often cause mirna expression change. So the paper of micrornas single nucleotide polymorphisms in the role of hepatocellular carcinoma （HCC）.

关 键 词：核苷酸 肝癌 细胞增殖 多态性 

分 类 号：R73-3[医药卫生—肿瘤]