负压封闭引流对糖尿病足肉芽组织PDGFR表达的影响及其临床意义  

Influence of vacuum sealing drainage on PDGFR expression of granulation tissue for diabetic foot and its clinical significance

作　　者：梁焯辉[1] 赵凡[1] 刘倩雯[1] 

机构地区：[1]广东省江门市人民医院内分泌科,广东江门529000

出　　处：《中国当代医药》2015年第11期43-45,共3页China Modern Medicine

基　　金：广东省江门市科技局课题(20120020046628)

摘　　要：目的探讨负压封闭引流（VSD）技术对糖尿病足肉芽组织PDGFR表达的影响及其临床意义。方法选择2010年1月~2014年2月在本院住院的糖尿病足2~3级的患者60例。将患者随机分成负压组和对照组,每组30例。负压组患者采用VSD技术治疗,对照组患者采用常规湿性换药的方法治疗。两组患者进行肉芽组织活检并比较两组的PDGFR含量。结果正常皮肤组织、溃疡边缘组织、溃疡组织中的血小板源性生长因子（PDGF）含量差异无统计学意义（P〉0.05）,但溃疡组织中的PDGFR含量明显降低（P〈0.05）。两组治疗前的PDGF亚基及PDGFR亚型含量差异无统计学意义（P〉0.05）;两组治疗后的PDGFR-α、PDGFR-β含量与治疗前比较,差异有统计学意义（P〈0.05）;负压组治疗后的PDGFR-α、PDGFR-β含量与对照组比较,差异有统计学意义（P〈0.05）。结论 VSD技术能增加局部皮肤的血液循环,增加PDGFR含量,刺激成纤维细胞增生,具有一定的推广应用价值。Objective To investigate the influence of vacuum sealing drainage（VSD） on PDGFR expression of granulation tissue for diabetic foot and its clinical significance. Methods 60 patients with diabetic foot of class 2-3 treated in our hospital from January 2010 to February 2014 were selected and they were randomly divided into negative pressure group（n=30） and control group（n=30）.Negative pressure group was treated with VSD technology,while control group was treated with conventional wet dressing.Patients of two groups were given granulation tissue biopsy and PDGFR content between two groups was compared. Results There was no statistical difference of platelet derived growth factor（PDGF） content among the normal skin tissue,the ulcer margin tissue and ulcer tissue（P〉0.05）,but PDGFR content of ulcer tissue was obviously decreased（P〈0.05）.There was no statistical difference of PDGF subunit and PDGFR subtype content before treatment between two groups（P〉0.05）,and there was a statistical difference of PDGFR-α and PDGFR-βcontent after treatment compared with before treatment（P〈0.05）,and there was a statistical difference of PDGFR-α and PDGFR-βcontent after treatment in negative pressure group compared with control group（P〈0.05）. Conclusion VSD technology can increase the blood circulation of local skin,increase the PDGFR content,and stimulate the proliferation of fibroblast.It has certain promotion and application value.

关 键 词：负压封闭引流 糖尿病足 肉芽组织 PDGFR 表达 影响 

分 类 号：R587.2[医药卫生—内分泌]