Background and Aims:The role of platelet autophagy in cirrhotic thrombocytopenia(CTP)remains unclear.This study aimed to investigate the impact of platelet autophagy in CTP and elucidate the regulatory mechanism of hy...
supported by the Natural Science Foundation of Xiamen City(3502Z20227307);the National Natural Science Foundation of China(81472458,82372809);the Special Fund for Public Welfare Research Institutes of Fujian Province(2023R1001001,2023R1001003,2023R1035).
The high mortality rate associated with gastric cancer(GC)has resulted in an urgent need to identify novel therapeutic targets for GC.This study aimed to investigate whether GAIP interacting protein,C terminus 1(GIPC1...
supported by the National Key Research and Development Projects(2018YFC1105400);the National Natural Science Foundation of China(81872173,82072959,and 31870959);the Zhejiang Provincial Natural Science Foundation(GF22H068757);the Zhejiang Undergraduate Talent Project(2021R401214).
Platelet-derived growth factor-BB(PDGF-BB)/platelet-derived growth factor receptor-β(PDGFR-β)pathway is conventionally considered as an important pathway to promote osteogenesis;however,recent study suggested its ro...
supported by the National Natural Science Foundation of China(82020108021);the Chongqing Special Project for Academicians(cstc2020yszx-jcyj X0004);the Project of the Trauma;Burns and Combined Injury State Key Laboratory(SKLYQ201901,SKLKF201802);the Training Plan of the Innovation Ability of Military Medical Frontier Research(2019CXJSB014,2019CXJSB004);the Project of the Science and Technology Fund of Guizhou Provincial Department of Health(gzwjkj2020-1-106)。
Sepsis,defined as life-threatening organ failure caused by a dysregulated host response to severe infection,is a major cause of death among intensive care unit patients.Therapies targeting on immunomodulatory is a new...
Objective:This study evaluated the safety and preliminary efficacy of vorolanib,a novel tyrosine kinase inhibitor,for treatment of patients with advanced solid tumors.Methods:During dose escalation,patients received i...