GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling  

作　　者：TINGTING LI WEI ZHONG LIU YANG ZHIYU ZHAO LI WANG CONG LIU WANYUN LI HAIYAN LV SHENGYU WANG JIANGHUA YAN TING WU GANG SONG FANGHONG LUO 

机构地区：[1]Cancer Research Center,School of Medicine,Xiamen University,Xiamen,361000,China [2]Department of Pharmacy,Xiamen Mental Health Center,Xiamen Xianyue Hospital,Xiamen,361000,China

出　　处：《Oncology Research》2024年第2期361-371,共11页肿瘤学研究（英文）

基　　金：supported by the Natural Science Foundation of Xiamen City(3502Z20227307);the National Natural Science Foundation of China(81472458,82372809);the Special Fund for Public Welfare Research Institutes of Fujian Province(2023R1001001,2023R1001003,2023R1035).

摘　　要：The high mortality rate associated with gastric cancer(GC)has resulted in an urgent need to identify novel therapeutic targets for GC.This study aimed to investigate whether GAIP interacting protein,C terminus 1(GIPC1)represents a therapeutic target and its regulating mechanism in GC.GIPC1 expression was elevated in GC tissues,liver metastasis tissues,and lymph node metastases.GIPC1 knockdown or GIPC1 blocking peptide blocked the platelet-derived growth factor receptor(PDGFR)/PI3K/AKT signaling pathway,and inhibited the proliferation and migration of GC cells.Conversely,GIPC1 overexpression markedly activated the PDGFR/PI3K/AKT signaling pathway,and promoted GC cell proliferation and migration.Furthermore,platelet-derived growth factor subunit BB(PDGF-BB)cytokines and the AKT inhibitor attenuated the effect of differential GIPC1 expression.Moreover,GIPC1 silencing decreased tumor growth and migration in BALB/c nude mice,while GIPC1 overexpression had contrasting effects.Taken together,our findings suggest that GIPC1 functions as an oncogene in GC and plays a central role in regulating cell proliferation and migration via the PDGFR/PI3K/AKT signaling pathway.

关 键 词：GIPC1 PDGFR Gastric cancer Proliferation MIGRATION 

分 类 号：R730.2[医药卫生—肿瘤]