P-gp和HIF-1α在原发性胆囊癌中的表达及其临床意义  

Expressions and clinical significance of P-gp and HIF-1α in primary gallbladder carcinoma

作　　者：赵艳飞[1] 于耀利[1] 贾志勇[1] 闫斌[1] 

机构地区：[1]包头医学院第一附属医院普外科二病区,包头014010

出　　处：《中国当代医药》2015年第11期49-51,共3页China Modern Medicine

摘　　要：目的探讨原发性胆囊癌中P-糖蛋白(P-gp)、缺氧诱导因子-1α(HIF-1α)的表达及临床意义。方法应用免疫组织化学方法(S-P法)对36例胆囊癌组织、20例胆囊息肉组织中P-gp和HIF-1α的表达情况进行检测,探讨两者的关系及其与胆囊癌之间的关系。结果胆囊癌组织中P-gp阳性表达28例(77.78%),HIF-1α阳性表达21例(58.33%),两者共同表达18例。胆囊息肉组织中P-gp、HIF-1α阳性表达分别为4例(20%)和0例(0%),P-gp、HIF-1α表达呈正相关(r=0.388,P<0.05)。结论 P-gp、HIF-1α蛋白可作为胆囊癌诊断的辅助指标,HIF-1α蛋白可作为评价及逆转肿瘤多药耐药的新指标。Objective To explore the expression and clinical significance of P-glycoprotain（P-gp） and hypoxia-inducible factor-1α（HIF-1α） in primary gallbladder carcinoma. Methods The expression of P-gp and HIF-1α in tissue of gallbladder carcinoma in 36 and tissue of gallbladder polyp in 20 was detected by immunohistochemistry（S-P method）.The relationship between the two expression and their relationship with gallbladder carcinoma was discussed.Results The positive expression of P-gp in gallbladder carcinoma was 28 cases（77.78%）,and HIF-1α was 21 cases（58.33%）,co-expression were 18 cases.The positive expression of P-gp and HIF-1α in tissue of gallbladder polyp was4（20%） and 0（0%） respectively.The expression of P-gp and HIF-1α had a positive correlation（r=0.388,P0.05）.Conclusion P-gp and HIF-1α protein can be considered as auxiliary indexes to diagnose gallbladder carcinoma.HIF-1α protein can be selected as a new index to evaluate and reverse multidrug resistance on tumors.

关 键 词：P-糖蛋白 缺氧诱导因子-1Α 原发性胆囊癌 

分 类 号：R735.8[医药卫生—肿瘤]