Ⅱb期宫颈癌根治术联合术前同期放化疗与根治性放疗联合同期化疗的临床疗效比较  

A clinical efficacy comparative study of phase Ⅱb radical hysterectomy plus preoperative chemoradiotherapy and radical radiotherapy plus concomitant chemotherapy on treating cervical cancer

作　　者：栾彦[1] 刁海丹[1] 李江宁[1] 徐林[1] 郝丹[1] 

机构地区：[1]大连市第三人民医院,辽宁大连116033

出　　处：《中医临床研究》2015年第4期122-124,共3页Clinical Journal Of Chinese Medicine

摘　　要：目的:比较IIb期宫颈癌行根治术联合术前同期放化疗与根治性放疗联合同期化疗的临床疗效。方法:回顾分析2002年7月-2008年12月我院收治的79例IIb期宫颈癌患者,48例行根治手术结合术前同期放化疗(观察组),31例行根治性放疗结合同期化疗(对照组)。结果:观察组的5年总生存率(OS)为83.3%,5年无进展生存率(PFS)为79.2%,对照组则分别为58.1%、54.8%,两组比较差异有统计学意义。观察组复发率(20.8%)较对照组(45.2%)明显降低(P<0.05)。观察组下肢水肿发生率较高,对照组放射性肠炎、膀胱炎发生率较高,差异有统计学意义(P<0.05),两组患者肠梗阻、泌尿生殖道瘘发生率差异无统计学意义(P>0.05)。结论:IIb期宫颈癌患者,根治术联合术前同期放化疗能获得较长生存期。虽然增加了下肢水肿发生率,但减少了放射性肠炎、膀胱炎发生率。Objective： To compare clinical efficacy of radical surgery plus previous concurrent chemoradiotherapy and radical radiotherapy plus concurrent chemotherpy in FIGO stage IIb cervical cancer. Methods：In 79 patients with cervical cancer in FIGO stage II, 48 patients received radical surgery and previous concurrent chemoradiotherapy （group 1）, 31 patients received radical radiotherapy and concurren chemotherapy （group 2）. Results： The 5-year overall survival rate （OS） was 83.3%in group 1 and 58.1%in group 2, and the 5-year disease-free survival rate （PFS） was 79.2%in group 1 and 54.8%in group 2, the difference was significant. The recurrence rate in group 1 was lower than that in group 2. Edema of lower extremity in group 1 was higher than that in group 2. Radiation enteritis and radiocystitis in group 1 was lower than that in group 2, and the difference was significant. Intestinal obstruction and urogenital tract fistula in group 1 were similar to those in group 2 （P〉0.05）. Conclusions：Patients had longer lifetime in group 1 than the group 2. In group 1 more lege edema happened than in group 2, but the rate of radiation enteritis and radiocystitis were lower.

关 键 词：宫颈肿瘤 手术 放化疗 

分 类 号：R73[医药卫生—肿瘤]