补体与牙周炎发生发展及其治疗  

The occurrence and development of complement and periodontitis and its treatment

作　　者：李娜[1] 高爱超[1] 王丽丽 于海燕 于维先[1,2] 

机构地区：[1]吉林大学口腔医院牙周科 [2]吉林省牙发育及颌骨重塑与再生重点实验室,长春130021

出　　处：《国际口腔医学杂志》2015年第3期344-347,共4页International Journal of Stomatology

基　　金：吉林省发展改革委员会科研项目(2013C022-4);吉林省卫生厅科研项目(2010z045)

摘　　要：在牙周炎这一慢性炎症反应过程中,补体不仅可以调解机体防御反应,保护宿主,还可直接作用于免疫细胞或通过调控信号转导通路,协助病原菌进一步感染和破坏牙周组织,最终导致免疫病理性的损伤反应。在免疫炎症反应中,补体不仅可刺激白细胞分泌白细胞介素、肿瘤坏死因子和粒细胞-巨噬细胞集落刺激因子,调节辅助性T细胞和巨噬细胞,促进细胞免疫和T细胞依赖的抗体分泌,增强免疫效应的调节,提高机体免疫力;亦可引起的炎症反应可对组织造成损伤,引起牙周炎。以补体受体拮抗剂干扰补体受体-Toll样受体信号转导通路,有利于机体清除病原菌,达到防治牙周炎的目的。理解补体在牙周炎发生发展中的作用,可为牙周炎治疗探索新途径。The complement system mediates the body＇s defense reactions to protect the host against periodontal chronic inflammatory diseases. This system assists pathogens to exacerbate pathological and destructive inflammation by directly affecting immune cells or via crosstalk and by regulating other host signaling pathways. The complement system induces secretion of interleukin, tumor necrosis factor, and granulocyte-macrophage colony-stimulating factor during immune inflammation. Secretion is stimulated by activating leukocytes, regulating helper T ceils and macrophages, and promoting cell immune and T cell-dependent antibody secretion, thus enhancing the regulation of immune effect and improving the body＇s immunity. Furthermore, the complement system produces inflammation that exacerbates tissue damage and triggers periodontitis. The antagonists of the complement receptor can significantly clean pathogens and prevent periodontitis by interfering the signaling crosstalk between the complement receptor and Toll-like receptors. Therefore, elucidating the mechanism of the complement system in periodontitis can provide novel targets for periodontitis therapeutics.

关 键 词：牙周炎 免疫炎症 补体 

分 类 号：R781.42[医药卫生—口腔医学]