去甲万古霉素静脉滴注引起视觉障碍1例  

Abnormal vision following intravenous infusion of demethylvancomycin

作　　者：谭昀杜熙 陈美芳[1] 杨薇[1] 

机构地区：[1]北京大学人民医院,北京100044

出　　处：《临床药物治疗杂志》2015年第2期88-90,共3页Clinical Medication Journal

摘　　要：患者,女性,58岁,因"发热伴咳嗽、咳痰加重9 d"以"肺部感染"收入院,完善相关检查后补充诊断感染性心内膜炎。患者青霉素皮试阳性,庆大霉素过敏,遂予去甲万古霉素0.8 g q12h联合左氧氟沙星0.4 g qd静滴抗感染治疗。去甲万古霉素第1次静滴约10 min后患者诉左眼视野内出现弹簧状"C"形强光斑,直径约10 cm,闭眼时不消失,无视力、视色、视野变化,无畏光等表现。停止输注去甲万古霉素,约半小时后强光斑逐渐消失,眼科会诊未见异常。更换为头孢曲松2 g qd联合左氧氟沙星0.4 g qd静脉抗感染治疗,症状未再出现。A 58-year-old woman was hospitalized with pulmonary infection and infective endocarditis. Since she was allergic to penicillin and gentamicin, demethylvancomycin （0.Sg q12h） and levofloxacin （0.4g qd） were intravenously infused. About l0 minutes after the first intravenous infusion of demethylvancomycin, the patient saw a strong spring-like C-shaped light spot with a diameter of 10 cm in the visual field of left eye, and the existetice this light spot still last even when her left eye was closed. No other clinical symptoms existed such as changes in vision, visual color and field and photaesthesia. Demethylvancomycin was stopped immediately. Thirty minutes later, the patient felt the gradual disappearance of strong light spot. Ophthalmological consultation showed no abnormality. In replace of demethylvancomycin, cefatriaxone was given and the symptom previously mentioned didn＇t appear.

关 键 词：去甲万古霉素 静脉滴注 视觉障碍 

分 类 号：R978.16[医药卫生—药品] R969.3[医药卫生—药学]