Ⅰ型和Ⅱ型精神分裂症血清5-羟色胺功能的初步研究  

A Preliminary Study on Serum Serotonin Functions of Type I and I of schizophrenia

作　　者：朱金富[1] 越学鼎 张秀明[1] 冯砚国[1] 胡宪章[1] 顾仁骏[1] 

机构地区：[1]河南省精神病医院,新乡453002

出　　处：《中原精神医学学刊》1998年第1期7-8,共2页

摘　　要：本文采用荧光分光光度法测定38例Ⅰ型精神分裂症患者和23例Ⅱ型精神分裂症患者治疗前后血清5-羟色胺浓度,并与36例健康对照组作比较,初步结果表明,Ⅰ型患者血清5-羟色胺浓度显著低于Ⅱ型患者和对照组(P<0.01),而后两者无明显差异(P>0.05),ⅠI型患者治疗前后血清5-羟色胺浓度有显著差异(P<0.05),Ⅱ型患者治疗前后血清5-羟色胺浓度无明显差异(P>0.05)。作者从5-羟色胺代谢中的生化联系对Ⅰ型和Ⅱ型精神分裂症的病理生理机制作了初步讨论。The serotonin concentrations of 38 type I and 23 type I of schizophrenias before and after treatment were determined and then compaired with that of 36 controls. The results showed that the serum serotonin concentration of type Ⅰ was siginficantly lower than that of type Ⅱ and control (P<0. 01) ,but laters had no marked defference(P>0. 05). The serum serotonin concentrations of type I before and after treatment had significanty deffenence(P<0. 05) , but type I had no. The authors also discussed pathogenic mechanism of type Ⅰ and type Ⅱ schizophrenia.

关 键 词：精神分裂症 血清 5-羟色胺 治疗 病理生理 

分 类 号：R749.3[医药卫生—神经病学与精神病学]