TGF-β1表达水平与原发性肝癌浸润及转移的关系  

Research on Relationship of TGF β1 Expression and Metastasis of Primary Liver Cancer

作　　者：张佳斌[1] 任辉[1] 纪旭[1] 冯学会[1] 李丽昕[1] 于德磊 王洪波[1] 刘振文[1] 

机构地区：[1]解放军302医院肝胆外科二中心,北京100039

出　　处：《现代生物医学进展》2015年第14期2666-2669,共4页Progress in Modern Biomedicine

基　　金：解放军302医院院长创新课题<利用计算机辅助技术建立基于肝癌总体积的新型肝移植患者入选标准>(YNKT2013020)

摘　　要：目的:探讨转化生长因子β1(TGF-β1)在原发性肝癌组织中的表达及其与肿瘤侵袭和转移的关系。方法:选择288例确诊为原发性肝癌患者作为研究组,另选取274例健康志愿者作为对照组。应用酶联免疫吸附法检测两组研究对象血清TGF-β1水平,免疫组织化学标记法检测肝癌患者肿瘤组织、癌旁组织及正常肝脏组织中TGF-β1的表达情况,并结合临床病理资料进行相关性分析。结果:原发性肝癌患者血清中TGF-β1水平明显高于对照组,差异具有统计学意义(P<0.01)。血清TGF-β1水平与肿瘤的组织学分级、浸润深度及转移呈正相关(P<0.01)。肝癌患者肿瘤组织中TGF-β1表达水平明显高于正常肝脏组织及癌旁组织,差异具有统计学意义(P<0.01)。结论:血清TGF-β1与原发性肝癌的侵袭和转移密切相关。TGF-β1可能会改变肿瘤微环境,增加侵袭和转移的潜力。Objective： To study the expression of TGF-β1 in primary liver cancer and the relationship with the invasion and metastasis for tumor. Methods： Serum levels of TGF-β1 of 288 cancer patients and 274 healthy volunteers were detected by means of enzyme-linked immunosorbent assay. Expression of TGF-β1 in liver cancer tissue was detected through the method of immunohistochemical markers, so as to analyze its relationship with clinical pathology of primary liver cancer. Results： TGF-β1 in the serum of patients with primary liver cancer was significantly higher than that in healthy control group （P〈0.01）. Elevated serum levels of TGF-β1 were closely related to level of histological grade, infiltration depth, and metastasis of tumor （P〈0.01）. TGF-β1 expression level in 288 cases ofhepatocellular carcinoma was significantly higher than that in the normal liver tissue and cancer adjacent tissues （P〈0.01）. Conclusion： The serum level of TGF-β1 was closely related to invasion and metastasis of primary liver cancer. TGF-β1 is likely to change the tumor microenvironment, and increase the potential of tumor invasion and metastasis. Serum levels of TGF-β1 expression level can be considered as a biological behavior and prognosis of primary liver cancer.

关 键 词：转化生长因子Β1 原发性肝癌 侵袭 转移 

分 类 号：R735.7[医药卫生—肿瘤]