对控制手术危险因素后原发性肝癌患者复发的影响因素研究  

Study of the influence factors on the recurrence patients with primary liver cancer after controlling the risk factors of operation

作　　者：邢永俊 叶冠雄[2] 吴文元[1] 杨越涛[1] 

机构地区：[1]浙江省丽水市人民医院二十二病区,浙江丽水323000 [2]浙江省丽水市人民医院肝胆外科,浙江丽水323000

出　　处：《中国现代医生》2015年第9期26-28,31,共4页China Modern Doctor

基　　金：浙江省公益性技术应用研究项目(2012C33034)

摘　　要：目的探讨对手术危险因素控制后原发性肝癌患者复发的影响因素研究。方法收集2008年6月~2013年6月期间本院住院治疗的肝癌且行肝切除手术患者285例,统计和分析的指标包括术前患者的一般资料、性别、年龄等基本资料;血液学指标：ALT、ALP、GGT;术中患者的相关指标：失血量以及手术时间;术后观察指标：肝功能情况及术后记录,根据病理结果确定肿瘤的直径、是否多个病灶、分化程度等指标,定期复查并记录复发的时间。结果术前GGT含量、肿瘤的直径、肿瘤病灶的个数、肿瘤的分化程度以及术后肝功能是否不全为肝癌患者三年复发的相关影响因素;术前GGT含量、肿瘤的直径、肿瘤病灶的个数、肿瘤的分化程度以及术后肝功能是否不全均为肝细胞癌症患者三年复发的独立影响因素。结论术前GGT含量、肿瘤直径、肿瘤病灶的个数、肿瘤的分化程度以及术后肝功能不全均为肝癌患者三年复发的独立影响因素,在临床上对具有该类特征的肝癌患者要引起足够重视,积极提升患者的预后。Objective To investigate the influence factors on the recurrence patients with primary liver cancer after controlling the risk factors of operation. Methods All 285 patients with primary liver cell cancer and underwent liver resection surgery in our hospital from June 2008 to June 2013, and analyzed the indicators included general data, such as patients gender, age and other basic information, and hematological indexes, such as alanine aminotransferase（ALT）, alkaline phosphatase （ALP）, glutamate transpeptidase （GGT）, and the relevant indicators during operation included the amount of blood loss undergoing the operation and the operation time, and observation indexes after operation including liver function, postoperative pathological results recorded according to determine tumor diameter, whether multiple lesions, differentiation degree, checked regularly and recorded the time of recurrence. Results The preoperative GGT content, tumor diameter, number of tumors, tumor differentiation degree and whether postoperative liver function is complete or not were related factors to the liver eel1 cancer patients three years recurrence; Preoperative GGT content, tumor diameter, number of tumors, tumor differentiation degree and whether postoperative liver function is complete or not were independent prognostic factors of hepatocellular cancer patients three years recurrence. Conclusion The pre- operative GGT level, tumor diameter, number of tumors, tumor differentiation degree and postoperative liver function are independent prognostic factors of hepatocellular cancer patients three years recurrence, we should cause enough at- tention on this kind of feature of patients with hepatocellular cancer in clinical, actively improve the prognosis of the patients.

关 键 词：手术危险因素 原发性肝癌 复发 影响因素 

分 类 号：R735.7[医药卫生—肿瘤]