腺泡状软组织肉瘤的针吸细胞学诊断  

Cytological diagnosis of alveolar soft part sarcoma needle aspiration

作　　者：朱思国[1] 王飞 余波 

机构地区：[1]湖北省监利县人民医院检验科,湖北监利433300 [2]湖北省宜昌市中心医院病理科,湖北宜昌443000 [3]湖北省襄阳市第一人民医院检验科,湖北襄阳441000

出　　处：《中国现代医生》2015年第9期63-66,F0003,共5页China Modern Doctor

摘　　要：目的探讨针吸细胞学对腺泡状软组织肉瘤的诊断要点与价值。方法回顾11例ASPS的FNAC资料及相关临床表现,观察ASPS的细胞学特征,分析其诊断价值。结果 11例中男4例,女7例,平均年龄27.2岁,10例肿块位于下肢,1例在乳房与下肢各有一肿块。ASPS的细胞学具有一定的共同特征:吸出血性标本、瘤细胞胞浆丰富嗜酸、部分为裸核、核圆形、核仁明显,最为明显的特征是有多种形态的结晶小体。结论利用ASPS的细胞学特征,尤其是多种形态的结晶小体可与化学感受器瘤、透明细胞肉瘤、腺泡状横纹肌肉瘤、透明细胞癌等鉴别。FNAC是术前诊断ASPS的极为有效的方法 。Objective To explore the diagnostic criteria and clinical value of fine needle aspiration cytology （FNAC） for alveolar soft part sarcoma （ASPS）. Methods The data of FNAC and related clinical manifestations of 11 ASPS cases were reviewed, and cytological features were observed, in order to analyze the diagnostic value of FNAC in ASPS. Results Among the 11 ASPS cases, four were males and seven were females, with the average age of 27.2 years old. The locations of the ASPS in ten cases were found in lower extremity, and one case in both breast and lower extremity. The cytological features of ASPS were similar in some aspects, such as suction of hemorrhagic specimen, tumor ceils with abundant cytoplasm, part of tumor cells characterized with bare nucleus, rounded nucleus, and distinct nucleolus in nuclei, and the most obvious characterization with multi-morphological crystalline particles. Conclusion Cytological features of ASPS, especially multi-morphological crystalline particles can distinguish ASPS from chemodectoma, clear cell sarcoma, alveolar rhabdomyosarcoma, and clear cell carcinoma. Therefore, FNAC is an extremely effective method for preoperative diagnosis of ASPS.

关 键 词：腺泡状软组织肉瘤 针吸细胞学 诊断 

分 类 号：R738.6[医药卫生—肿瘤]