免疫组织化学在肺小细胞癌诊断中的应用  

Application of Immunohistochemistry in the Diagnosis of Small Cell Lung Carcinoma

作　　者：汪美华[1] 凌扬[1] 周林艳[1] 

机构地区：[1]苏州大学附属常州肿瘤医院,江苏常州213001

出　　处：《肿瘤基础与临床》2015年第2期148-150,共3页journal of basic and clinical oncology

摘　　要：目的目的探讨免疫组织化学在肺小细胞癌(SCLC)诊断中的作用。方法应用免疫组织化学方法对肺肿瘤穿刺和支气管镜活检标本疑似SCLC的72例标本检测TTF1、Napsin A、CK5/6、P63、CD56、Syn、Cg A、CD45、Ki67的蛋白表达,分析SCLC的病理形态特征与免疫表型。结果 SCLC易出现"人工挤压现象";结合免疫组织化学染色结果,72例疑似SCLC者最后诊断为SCLC 65例,低分化鳞癌5例,非典型类癌2例。结论免疫组织化学在SCLC的诊断与鉴别诊断中具有十分重要的作用。Objective To investigate the role of immunohistochemistry in the diagnosis of small cell lung carcinoma （SCLC）. Methods The protein expressions of TTF1, NapsinA, CK5/6, P63, CD56, Syn, CgA, CIM5 and Ki67 in the 72 cases of percutaneous lung biopsy of bronchoscopic biopsy specimens suspected as SCLC were examined by immunohistological method, and the pathological characteristics and immunophenotype were analyzed. Results Artificial pressure could be observed in most of SCLC; Of the 72 patients suspected as SCLC, 65 patients were small cell lung carcinoma,5 patients poorly differentiated squamous cell carcinoma and 2 patients atypical carcinoid. Conclusion Immunohistochemistry is a great role in the diagnosis and differential diagnosis of SCLC.

关 键 词：肺肿瘤 小细胞癌 免疫组织化学 诊断 

分 类 号：R734.2[医药卫生—肿瘤] R730.4[医药卫生—临床医学]