结肠癌患者血清脂联素和胃饥饿素水平的临床分析  

Clinical Significance of Serum Adiponectin and Ghrelin in Patients with Colorectal Cancer

作　　者：毕建成[1] 田伟[1] 王国文[2] 陈正立[3] 耿玉兰[3] 

机构地区：[1]河北省中医院检验科,河北石家庄050000 [2]石家庄市第三医院检验科,河北石家庄050000 [3]河北医科大学第一医院检验科,河北石家庄050031

出　　处：《标记免疫分析与临床》2015年第4期291-293,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：目的检测结肠癌患者血清脂联素和胃饥饿素水平,并探讨二者的关系。方法收集2010年1月至2013年12月的82例结肠癌患者和30例同期健康体检者血液。分别使用酶联免疫吸附分析(enzyme-linked immunosorbent assay,ELISA)方法和放射免疫法检测结肠癌患者和对照组血清脂联素和胃饥饿素水平。比较结肠癌患者与对照组和未转移组和淋巴结转移组脂联素和胃饥饿素水平,并对结肠癌患者血清脂联素和胃饥饿素水平进行相关性分析。结果结肠癌患者血清脂联素水平显著低于健康对照组(5.51±2.33ng/L vs.13.96±2.95ng/L,P<0.0001);淋巴结转移组明显低于未转移组患者(3.62±2.03ng/L vs.6.91±5.12ng/L,P<0.001)。结肠癌患者血清胃饥饿素水平显著高于对照组(156.0±55.1pmol/L vs.58.5±25.9pmol/L,P<0.001);淋巴结转移组明显高于未转移组患者(164.8±15.1pmol/L vs.93.2±20.9pmol/L,P<0.001)。结肠癌患者血清脂联素与饥饿素水平无相关性(r=0.083,P=0.729)。结论血清脂联素水平降低和胃饥饿素水平升高与结肠癌发病和转移显著相关,提示血清脂联素和胃饥饿素检测对于结肠癌的早期诊断和病程有一定的临床意义。Objective To determine the serum levels of adiponectin and ghrelin in patients with colorectal cancer and to explore their correlations. Methods The serum levels of adiponectin and ghrelin in 82 colorectal cancer patients and 30 healthy controls were detected by enzyme-linked immunosorbent assay （ELISA）and radioimmunoassay. Results The mean level of adiponectin in colorectal cancer patients was obviously lower than that in the controls（5.51 ±2.33 ng/L vs. 13.96 ±2.95 ng/L, P 〈0. 0001 ）. The serum adiponectin level in nodal metastasis patients was significantly lower than that in un-metastasis patients（3.62 ± 2.03 ng/L vs. 6.91 ± 5.12ng/L, P 〈0.0001 ）. The serum ghrelin levels in patients with colorectal cancer were that of controls （ 156.0 ± 55.1 pmol/L vs. 58.5 ±25.9 pmol/L, P 〈 0.0001 ）. The serum significant higher than ghrelin levels in nodal metastasis patients were significantly higher than that in un-metastasis patients（ 164.8 ±15.1 pmol/L vs. 93.2 ± 20.9 pmol/L, P 〈 0. 0001 ）. There was no correlation between serum adiponection and ghrelin in colorectal cancer patients （ r = 0. 083, P = 0. 729 ）. Conclusion The decreased adiponectin and increased ghrelin are obviously related to both outbreak and metastasis of co｜orecta｜ cancer, it may suggest that the detection of serum adiponectin and ghrelin are significant in both early diagnosis and course of colorectal cancer.

关 键 词：脂联素 胃饥饿素 结肠癌 转移 

分 类 号：R735.35[医药卫生—肿瘤] R730.43[医药卫生—临床医学]