幽门螺杆菌L型感染对胃癌侵袭和转移能力的影响  

Influence of L-type Helicobacter pylori infection on invasion and metastasis of gastric cancer

作　　者：罗永健 鄢家明 鲜义 

机构地区：[1]甘洛县人民医院病理科,四川凉山616850 [2]越西康虹医院内科,四川简阳616650 [3]越西康虹医院胃镜科,四川简阳616650

出　　处：《国际检验医学杂志》2015年第8期1113-1114,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨幽门螺杆菌L型(Hp-L型)感染对胃癌侵袭和转移能力的影响。方法选取胃癌患者80例,每例患者采集癌组织及癌旁正常组织各1份,制作切片标本,采用革兰染色、免疫组化染色、透射电镜对组织标本进行Hp-L型、基质金属蛋白酶-9(MMP-9)、血管内皮生长因子(VEGF)检测。结果癌组织标本Hp-L型阳性率为67.50%,高于癌旁正常组织的23.75%(P<0.05)。癌组织标本MMP-9、VEGF阳性率均高于癌旁正常组织(P<0.05)。Hp-L型阳性癌组织VEGF、MMP-9阳性率均高于Hp-L型阴性癌组织(P<0.05)。胃癌组织Hp-L型阳性率与癌细胞局部和远处淋巴结转移及侵袭深度相关,与肿瘤大小无关。结论 Hp-L型感染与胃癌的发生密切相关,也有可能对胃癌转移和侵袭产生影响。Objective To investigate the influence of L‐type Helicobacter pylori（Hp‐L） infection on invasion and metastasis of gastric carcinoma .Methods Carcinoma tissues and normal tissues were collected from 80 patients with gastric cancer ,and detected for Hp‐L ,matrix metalloproteinases‐9（MMP‐9） and vascular endothelial growth factor（VEGF） by using Gram staining ,immuno‐histochemistry staining and transmission electron microscope .Results Positive rate of Hp‐L in carcinoma tissues was 67 .50% , higher than the 23 .75% of normal tissues（P〈0 .05） .Positive rates of MMP‐9 and VEGF of carcinoma tissues were also higher than normal tissues（P〈0 .05） .Positive rates of VEGF and MMP‐9 of carcinoma tissues positive with Hp‐L were higher than carci‐noma tissues negative with Hp‐L（P〈0 .05） .The positive rate of Hp‐L in carcinoma tissues was correlated with local and distant lymph node metastasis ,and invasion depth ,but not correlated with the size of tumor .Conclusion Hp‐L infection might be correla‐ted with carcinogenesis of gastric cancer ,and could also influence metastasis and invasion of gastric cancer .

关 键 词：幽门螺杆菌L型 胃癌 侵袭 转移 

分 类 号：R735.2[医药卫生—肿瘤]