厄贝沙坦治疗IgA肾病临床疗效观察  

Curative Effect of Irbesartan on Ig A Nephropathy

作　　者：刘学清[1] 高风[1] 李妍[1] 李长荣[1] 赵健新[1] 

机构地区：[1]北京军区北戴河疗养院,河北秦皇岛066100

出　　处：《河北医学》2015年第7期1142-1144,共3页Hebei Medicine

摘　　要：目的:观察厄贝沙坦对Ig A肾病的疗效及其安全性。方法:将Ig A肾病患者62例随机分为治疗组32例和对照组30例。治疗组给予双嘧达莫150mg/d、厄贝沙坦150mg^300mg/d,共12周;对照组单纯给予双嘧达莫150mg/d,共12周;观察两组患者治疗前后收缩压、舒张压、24h尿蛋白定量、血尿素氮、肌酐和血K±等变化。结果:治疗12周后治疗组患者收缩压(SBP)、舒张压(DBP)、24h尿蛋白定量、血尿素氮(BUN)、肌酐均降低(P<0.05);对照组患者用药后收缩压(SBP)、舒张压(DBP)、24h尿蛋白定量、血尿素氮(BUN)、肌酐均无明显降低(P>0.05)。结论:厄贝沙坦治疗Ig A肾病能明显降低血压、减少尿蛋白,改善肾功能,且无明显不良反应。Objective：To investigate the effect and the safety of irbesartan on IgA nephropathy.Meth-od：Sixty-two cases of IgA nephropathy were randomly divided into treatment group and control group.Pa-tients of treatment group （ n=32） were given 150mg dipyridamole and 150~300mg irbesartan, and the pa-tients of control group （ n=30） were given 150mg dipyridamole per day for 12 weeks.Systolic blood pressure, diastolic blood pressure, proteinuria in 24 hours, blood urea nitrogen, creatinine and potassium were ob-served.Result：Systolic blood pressure, diastolic blood pressure, proteinuria in 24 hours, blood urea nitro-gen and creatinine in treatment group decreased obviously （P〈0.05）.There was no decrease（P〉0.05） in control group after treatment.Conclusion： Irbesartan can obviously reduce blood pressure and proteinuria, improve renal function without severe side-effects in treating IgA nephropathy.

关 键 词：双嘧达莫 厄贝沙坦 IG A肾病 

分 类 号：R692[医药卫生—泌尿科学]