无乳头溢液的乳腺导管内乳头状瘤84例临床分析  

Clinical analysis of 84 cases of intraductalpapilloma of breast without nipple discharge

作　　者：朱婧[1] 朱大江[1] 周东华[1] 郭钊轩[1] 陈金桃[1] 马诺[1] 周志升[1] 张颖[1] 

机构地区：[1]佛山市妇幼保健院乳腺疾病防治中心,528000

出　　处：《中华内分泌外科杂志》2015年第2期132-135,共4页Chinese Journal of Endocrine Surgery

摘　　要：目的：总结无乳头溢液的乳腺导管内乳头状瘤（ intraductal papilloma ， IP）的临床特点、诊断及手术方式。方法回顾分析佛山市妇幼保健院2011年2月至2013年10月期间收治的84例（130个病灶）无乳头溢液症状的IP患者的临床资料。结果84例共130个病灶，年龄段主要分布于30～50岁，病灶长径≤10 mm 113个（86.92％），病灶位置距离乳头≤20 mm 84个（64.42％）；病理诊断IP合并腺病57个，IP合并纤维囊性腺病43个，IP合并纤维腺瘤48个，IP伴导管上皮增生14个，IP伴导管上皮非典型增生2个。随访3～36个月，复发5例，其中4例为IP，1例为导管原位癌。结论无乳头溢液的IP多无典型临床症状，超声检查可有不典型阳性发现，术前诊断符合率低，可积极手术活检。多发性及伴导管上皮不典型增生IP患者术后有一定复发率，应密切随访。Objective To summarize the clinical characteristics , diagnosis and surgical method of intra-ductal papilloma（IP）of breast without nipple discharge .Methods The clinical data of 84 IP patients（130 le-sions）without nipple discharge admitted from Feb .2011 to Oct.2013 were analyzed retrospectively .Results The age of the 84 patients were mainly ranging from 30 to 50 years old.113（86.92%）lesions were≤10 mm in size, 84（64.42%）lesions had a distance≤20 mm to nipple, 57 accompanied by adenosis , 43 accompanied by fibro-cystic adenosis , 48 accompanied by fibroadenoma , 14 with ductal hyperplasia , and 2 with atypical ductal hyper-plasia.After a follow-up of 3 to 36 months, 5 cases had recurrence , including 4 cases of IP and 1 case of ductal carcinoma in situ.Conclusions IP without nipple discharge has no typical clinical symptoms .Ultrasound exam-ination may have positive findings , but not typical .Preoperative diagnosis is difficult and surgical biopsy is rec-ommended.Multiple and atypical ductal hyperplasia has possibility of recurrence , so follow-up is necessary.

关 键 词：导管内乳头状瘤 乳头溢液 超声检查 

分 类 号：R737.9[医药卫生—肿瘤]