CD147、MCT1及MCT4在宫颈病变中的表达及临床意义  

Expression and Clinical Significance of CD147,MCT1 and MCT4 in Cervical Lesions

作　　者：张宝月[1] 瞿全新[2] 顾安康[3] 

机构地区：[1]天津海洋石油总医院,300452 [2]天津市第一中心医院 [3]天津市中医药研究院附属医院病理科

出　　处：《国际妇产科学杂志》2015年第2期194-196,共3页Journal of International Obstetrics and Gynecology

摘　　要：目的：探讨CD147、单羧酸转运蛋白1（MCT1）、MCT4在宫颈上皮内瘤样病变（CIN）及宫颈癌中的表达及其临床意义。方法：选择宫颈病变患者92例,其中宫颈癌43例（宫颈癌组）,CIN 34例（CIN组,CINⅠ12例、CINⅡ11例、CINⅢ11例）,15例正常宫颈作为对照（对照组）。采用免疫组化SP法检测CD147、MCT1、MCT4表达情况并进行分析。结果：CD147、MCT1、MCT4阳性表达率,宫颈癌组高于CIN组（均P〈0.05）和对照组（均P〈0.05）,CIN组高于对照组（均P〈0.05）,CINⅡ-Ⅲ组高于CINⅠ组（均P〈0.05）。在宫颈癌组中,CD147、MCT1阳性表达率,年龄≤35岁组低于年龄〉35岁组,Ⅰ-Ⅱ期组低于Ⅲ-Ⅳ期组,高分化组低于中低分化组（均P〈0.05）;MCT4阳性表达率,年龄≤35岁组低于年龄〉35岁组,高分化组低于中低分化组（均P〈0.05）,Ⅰ-Ⅱ期组与Ⅲ-Ⅳ期组差异无统计学意义。在宫颈病变组织中,MCT1和CD147的表达一致性有统计学意义（加权的Kappa=0.774,Z=10.126,P〈0.001）。MCT4和CD147的表达一致性有统计学意义（加权的Kappa=0.909,Z=11.628,P〈0.001）。MCT1和MCT4的表达一致性有统计学意义（加权的Kappa=0.797,Z=10.383,P〈0.001）。结论：CD147、MCT1、MCT4的表达在宫颈病变中具有较高的一致性,在CIN及宫颈癌发生发展中发挥重要作用,同时可作为判断低级别CIN进展为高级别CIN及宫颈癌的高危客观指标,对于有CD147、MCT1、MCT4高表达的高级别或低级别CIN患者均应予以积极治疗及密切随访。Objective： To study the expression and clinical significance of CD147, monocarboxylate transporters Ⅰ （MCT1） and MCT4 in cervical lesions and cervical cancer. Methods：Choose 92 patients with cervical lesions, including 43 cases of carcinoma of the cervix （cervical cancer group）, 34 cases with CIN（CIN group, 12 eases of CIN Ⅰ , Ⅱ cases of CINⅡ , 11 cases of CIN Ⅲ ）, 15 cases of normal cervical as controls （control group）. Immunohistochemistry was used to test and analyze the expression of CD147, MCT1 and MCT4. Results：The positive expression rates of CD147, MCT1 and MCT4 in cervical cancer group was higher than that in CIN group （all P〈0.05） and control group （all P〈0.05）. CIN group was higher than control group（all P〈 0.05 ）, CIN Ⅱ-Ⅲ group was higher than CIN I group （all P〈0.05 ）. In cervical carcinoma group, the positive expression rates of CD147 and MCT1 in age〈35 years old group was lower than that in the group of age〉35 years old group, that of stage Ⅰ-Ⅱ group is lower than stage Ⅲ-Ⅳ, and that of high differentiation group was lower than that in low differentiation group （all P〈0.05 ）. In cervical carcinoma group, the positive expression rates of MCT4 in aged ≤ 35 years old group was lower than that in the group of age〉35 years old group, and that of high differentiation group was lower than that in low differentiation group （all P〈0.05）. Differences between stage Ⅰ -Ⅲ group and stage Ⅲ-Ⅳ group had no statistical significance. There was statistically significant consistency between the expression of MCT1 and CD147 （weighted Kappa=0.774,Z=10.126,P〈0.001）. There was statistically significant consistency between MCT4 and CD147 （weighted Kappa=0.909,Z=11.628,P〈0.001）. There was statistically significant consistency between MCT1 and MCT1 （weighted Kappa=0.797,Z=10.383,P 〈0.001）. Conclusions：The expression of CD147, MCT1, MCT4 were consistently higher level in cervical lesions and play important role

关 键 词：宫颈肿瘤 宫颈上皮内瘤样病变 免疫组织化学 抗原 CD147 单羧酸转运蛋白 

分 类 号：R737.33[医药卫生—肿瘤]