丹参酮ⅡA联合辛伐他汀治疗颈动脉粥样硬化的疗效观察  

Effect of TashinoneⅡA Combined with Simvastatin in the Treatment of Carotid Atherosclerosis

作　　者：周昱[1] 张长翼[2] 

机构地区：[1]汕头大学医学院第二附属医院神经内科,广东汕头515041 [2]汕头大学医学院第二附属医院心内科,广东汕头515041

出　　处：《汕头大学医学院学报》2015年第1期19-20,23,共3页Journal of Shantou University Medical College

摘　　要：目的:探讨丹参酮ⅡA联合辛伐他汀治疗颈动脉粥样硬化(CAS)的临床疗效。方法:82 CAS患者随机分为治疗组(予丹参酮ⅡA联合辛伐他汀)和对照组(予辛伐他汀),治疗3个月后检测总胆固醇、C-反应蛋白(CRP)水平、颈动脉内膜中层厚度(IMT)变化。结果:与对照组比,治疗组CRP降低,颈动脉IMT变薄(P<0.05)。结论:丹参酮ⅡA联合辛伐他汀能延缓、逆转CAS进展,增强斑块稳定性,值得临床推广。Objective： To investigate the effect of Tashinone ⅡA combined with simvastatin in the treatment of carotid atherosclerosis （CAS）. Methods： A total of 82 cases with CAS were randomly divided into treatment （given Tashinone ⅡA combined with simvastatin）and control（given simvastatin）groups. After 3 months of therapy, the total cholesterol, C-reactive protein （CRP） and carotid intima-media thickness （IMT） were detected. Results： Compared with control group, the CRP was lower, the IMT was thinner in the treatment group （P〈0.05）. Conclusion： The Tashinone ⅡA combined with simvastatin can delay and reverse the progress of CAS, and enhance the stability of atherosclerosis.

关 键 词：丹参酮ⅡA 辛伐他汀 动脉粥样硬化 C-反应蛋白 

分 类 号：R743[医药卫生—神经病学与精神病学]