血清s-100β蛋白在心肺复苏后脑损伤预后评估中的意义及乌司他丁对其的影响  

The Prognosis of Serum Protein s-100β on Brain Damage Following Cardiopulmonary Resuscitation and Effect of Ulinastain on s-100β

作　　者：舒周伍[1] 郑莉[1] 林鹏洲[1] 陈小华[1] 

机构地区：[1]汕头大学医学院第一附属医院心血管内科,广东汕头515041

出　　处：《汕头大学医学院学报》2015年第1期21-23,共3页Journal of Shantou University Medical College

摘　　要：目的：探讨血清s-100β蛋白对心脏骤停经心肺复苏（CPR）后患者脑损伤程度及预后评估价值及乌司他丁（UTI）的干预作用。方法：心脏骤停经CPR后存活〉72 h的患者（40例）随机分为常规治疗组和UTI组,每组20例,另选同期、同年龄段健康志愿者20人为正常对照组。CPR后3、6、12、24、48、72 h分别取血样本;ELISA法测定s-100β水平。结果：与正常对照组比,常规治疗和UTI组s-100β浓度均明显增高（P〈0.05）,6-12 h达峰值,随后逐步下降。与常规治疗组比,UTI组各时间点s-100β浓度均明显降低（P〈0.05）;UTI组在48 h后Glasgow评分明显升高（P〈0.05）。s-100β水平与Glasgow评分负相关。结论：s-100β水平能反映CPR后早期缺血缺氧性脑损伤程度,同时还可预测CPR后意识恢复情况。UTI治疗能降低s-100β,改善脑复苏后症状。Objective：To investigate the prognosis of serum protein s-100β on brain damage following cardiopulmonary resuscitation（CPR）and effect of Ulinastain（UTI）on s-100β. Methods：Forty patients who survived more than 72 hours with CPR were randomly divided into the conventional treatment and UTI groups, 20 cases for each group. Twenty healthy volunteers were selected as normal control group. Three,6,12,24,48 and 72 hours after CPR,the blood specimens were collected,and the s-100 β levels was determined by ELISA. Results：Compared with the normal control group,the levels of s-100β increased significantly in the conventional treatment and UTI groups（P〈0.05）and reached the peak in 6~12 hours,then gradually decline. Compared with the conventional treatment group,the levels of s-100β obviously decreased while the Glasgow score increased significantly in the UTI group after 48 hours（P〈0.05）. There was a negative correlation between level of s-100β and Glasgow score. Conclusion：s-100β can reflect the hypoxic ischemic brain damage in early CPR,and it can predict the recovery of consciousness after CPR. UTI treatment can decrease s-100β, and improve symptoms after cerebral resuscitation.

关 键 词：乌司他丁 血清S-100Β蛋白 脑损伤 心肺复苏 

分 类 号：R541.9[医药卫生—心血管疾病]