区域性动脉灌注新辅助化疗对进展期胃癌治疗的研究  

Effects of preoperative regional intra-arterial infusion chemotherapy for patients with advanced gastric cancer

作　　者：孙鑫荣[1] 秦连进[1] 唐成武[1] 冯文明[1] 鲍鹰[1] 费卯云[1] 郑银元[2] 朱沛枫 

机构地区：[1]湖州师范学院附属第一医院普外科,浙江湖州313000 [2]湖州师范学院附属第一医院介入科,浙江湖州313000

出　　处：《中国现代医生》2015年第13期81-84,共4页China Modern Doctor

基　　金：浙江省省部共建资助项目(WKJ-2012-2-037)

摘　　要：目的：探讨区域性动脉灌注新辅助化疗治疗进展期胃癌的疗效。方法回顾性分析82例临床芋、郁期胃癌患者接受区域性动脉灌注新辅助化疗（动脉灌注化疗组，42例）和静脉新辅助化疗（静脉化疗组，40例）的疗效,术前共2次，间隔28 d。两组均在第2次化疗后10～15 d接受手术。术后接受6个疗程的化疗。比较两组化疗毒副反应及生存率。结果两组化疗毒副反应无明显差异，两组中位生存期（动脉组25.3个月v s静脉组19.1个月）、3年生存率（动脉组36.4%v s静脉组21.0%）比较差异存在统计学意义（P〈0.05）。结论区域性动脉灌注新辅助化疗耐受性良好，有助于提高进展期胃癌患者的生存率。Objective To evaluate the effects of preoperative regional intra-arterial infusion chemotherapy for patients with advanced gastric cancer （AGC）. Methods A total of 82 patients with clinical stage Ⅲ,Ⅳ gastric cancer received two cycles of neoadjuvant regional intra-arterial infusion chemotherapy （arterial infusion group, n=42） or neoadjuvant systemic chemotherapy （systemic chemotherapy group, n=40）. The operation was administrated in 10 to 15 days before chemotherapy. All patients received 6 course of systemic chemotherapy after surgery. Chemotherapy toxicity and sur-vival rate were retrospectively analyzed. Results No significant difference was found in chemotherapy toxicity between two groups. The median survival period was 25.3 months in arterial infusion group and 19.1 months in systemic chemotherapy group. 3-year survival rate was 36.4% in arterial infusion group and 21.0% in systemic chemotherapy group respectively, there were significant differences （P〈0.05）. Conclusion Preoperative regional intra-arterial infusion chemotherapy is well tolerated in advanced gastric cancer patients and could improve short-term survival.

关 键 词：胃癌 新辅助化疗 动脉灌注 

分 类 号：R735.2[医药卫生—肿瘤]