优思明预处理对多囊卵巢综合征患者心理状态和临床疗效的影响研究  

Polycystic Ovary Syndrome Patients' Psychological States and Clinical Efficacy with Letrozole Treatment After Drospirenone and Ethinylestradiol Tablets Pretreatment

作　　者：柳顺玉[1] 阮祥燕[1] 刘玉兰[1] 殷冬梅[1] 

机构地区：[1]首都医科大学附属北京妇产医院内分泌科,北京100026

出　　处：《国际精神病学杂志》2015年第2期48-50,共3页Journal Of International Psychiatry

摘　　要：目的探讨优思明预处理对多囊卵巢综合征患者心理状态和临床疗效的影响。方法选择我院2013年1月~2014年1月就诊的116例多囊卵巢综合征不孕患者随机分为两组,对照组58例来曲唑治疗,观察组58例优思明3个月预处理后来曲唑治疗,比较两组患者的心理状态、激素水平变化以及来曲唑促排卵治疗4个月的排卵率、妊娠率。结果两组患者治疗前焦虑自评量表（SAS）、抑郁自评量表（SDS）评分差异均无统计学意义（P〉0.05）,治疗后两组SAS、SDS评分均显著下降,且观察组下降更明显,与对照组比较差异有统计学意义（P〈0.05）;两组治疗后,观察组促黄体生成素（LH）、睾酮（T）显著降低,与治疗前比较差异具有统计学意义（P〈0.05）,而对照组上述指标有所下降,但与治疗前比较差异无统计学意义（P〉0.05）;来曲唑促排卵治疗4个月,观察组的排卵率、妊娠率分别为78.6%、41.4%,均显著高于对照组的63.3%、27.6%,差异具有统计学意义（P〈0.05）。结论多囊卵巢综合征不孕患者给予优思明预处理,能够改善患者的心理状态及激素水平,提高排卵及妊娠率,是有效的临床治疗方案。Objective To investigate the influence of polycystic ovary syndrome patient’s psychological states and clinical efficacy with Letrozole treatment after Drospirenone and ethinylestradiol tablets pretreatment. Methods116 cases of polycystic ovary syndrome patients from January 2013 to January 2014 in our hospital were selected as the study object and they were randomly divided into two groups,58 cases of the control group were treated with Letrozole,58 cases of the observation group were treated with Letrozole after Drospirenone and ethinylestradiol tablets pretreatment,the patient’s psychological states and hormone levels,the ovulation rate,pregnancy rate after treatment and flowed up 4 months of two groups were compared. Results The self-evaluation of anxiety scale（ SAS）,depression self rating scale（ SDS） score of two groups before treatment were compared,there was no statistically significant difference（ P 〉 0. 05）,after treatment,the SAS,SDS scores of two groups were significantly decreased,and the amplitude of observation group was greater,there were statistically significant differences between two groups（ P 〈 0. 05）; after treatment,the patients’ luteinizing hormone（ LH）,testosterone（ T） of observation group was significantly reduced,compared with before treatment the difference was statistically significant（ P 〈 0. 05）,the index of control group had declined,but compared with before treatment the difference was not statistically significant（ P 〈 0. 05）; flowed up the patients for 4 months,the ovulation rate,pregnancy rate of observation group were78. 6%,41. 4%,significantly higher than 63. 3%,27. 6% of the control group,there were statistically significant differences（ P 〈 0. 05）. Conclusion Drospirenone and ethinylestradiol tablets pretreatment in polycystic ovary syndrome can significantly improve the patients’ psychological state and hormone levels,and improve ovulation and pregnancy,it is a valid clinical treatment.

关 键 词：多囊卵巢综合征 屈螺酮炔雌醇片(优思明) 来曲唑 焦虑自评量表(SAS)、抑郁自评量表(SDS) 

分 类 号：R749.05[医药卫生—神经病学与精神病学]