紫龙金片联合化疗治疗晚期非小细胞肺癌的研究观察  

Study of Zilongjin Tablets Combined with Chemotherapy on Advanced Non Small Cell Lung Cancer

作　　者：孙彩萍[1] 王建芳[1] 陈遐林[1] 叶万立[1] 朱晓灵[1] 刘秋霞[1] 

机构地区：[1]绍兴市人民医院浙江大学绍兴医院,浙江绍兴312000

出　　处：《中华中医药学刊》2015年第5期1145-1147,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药管理局项目(201273100757)

摘　　要：目的:考察紫龙金片联合化疗对晚期非小细胞肺癌的治疗效果。方法:对收治的晚期非小细胞肺癌患者128例随机分为实验组和对照组,实验组接受紫杉醇联合奈达铂化疗+紫龙金片治疗,对照组接受紫杉醇联合奈达铂化疗+安慰剂治疗,治疗2个周期后,分别检测患者的总体有效率、生活质量和免疫功能变化。结果:治疗组缓解率为45.3%,对照组为28.1%,治疗组优于对照组(P<0.05),控制率治疗组亦优于对照组(P<0.05);治疗组生活质量提高人数35例(54.7%),对照组为22例(34.4%),治疗组优于对照组(P<0.05);治疗后,治疗组CD4(31.25±4.35 vs 27.56±6.13)和CD4/CD8(1.23±0.21 vs 1.71±0.23)均显著优于对照组(P<0.01)。结论:紫龙金片联合化疗可有效治疗晚期非小细胞肺癌,改善患者生活质量,其机制可能与紫龙金片改善患者免疫功能有关。Objective：To examine treatment effect of the Zilongjin tablets combination chemotherapy onr advanced non - small cell lung cancer. Methods ： Selected128 cases of patients with advanced non - small cell lung cancer in our hospi- tal. Those patients were randomly divided into experimental group and control group, the experimental group accepted Nedaplatin plus paclitaxel chemotherapy ＋ Zilongjin tablets treatment, the control group accepted Nedaplatin plus paclita- xel chemotherapy ＋ placebo treatment. After 2 cycles treatment, detected the changes of overall effectiveness, life quality and immune function. Results ：The remission rate in the treatment group was 45.3%, the control group was 28. 1%, the treatment group was better than the control group （ P 〈 0.05 ） ; in the control rate, the treatment group was superior to the control group （P 〈0.05 ） ; The number of people who has a improved life quality in treatment group was 35 （54.7%） and control group was 22（ 34.4% ）, the treatment group was better than that of control group （ P 〈 0.05 ） ; After treat- ment, CD4（31.25 ＋4.35 vs 27.56 ＋6.13） and CD4/CDS（1.23 -＋0.21 vs 1.71 ＋0.23）in the treatment group were significantly better than control group （P 〈 0.01 ）. Conclusion：Zilon^in tablets combined with chemotherapy could effec- tive treatment of advanced non -small cell lung cancer, improved patient quality of life, its mechanism may be associated with the Zilongjin tablets could improve the patient~ immune function.

关 键 词：紫龙金片 化疗 晚期非小细胞肺癌 疗效 

分 类 号：R734.2[医药卫生—肿瘤]