消癌平注射液联合XELOX方案治疗晚期胃癌的效果分析  

Analysis of Xiaoaiping Injection Combined with XELOX Regimen in the Treatment of Advanced Gastric Cancer

作　　者：高亮[1] 卢丽琴[1] 洪朝金[1] 王永向[1] 

机构地区：[1]浙江省人民医院,浙江杭州310014

出　　处：《中华中医药学刊》2015年第5期1259-1261,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:探讨消癌平注射液联合XELOX方案治疗晚期胃癌的临床效果。方法:选取2008年6月—2012年6月医院确诊的183例晚期胃癌患者,采用奇偶数随机分组方法,将183例患者随机分为试验组92例,对照组91例,两组研究对象均接受奥沙利铂130 mg/m2,静脉滴注,每3周1次,希罗达2500 mg/(m2·d),分两次,口服14 d的化疗方案,化疗至少2个周期。试验组加用消癌平注射液40 m L/d,静脉滴注14 d。本研究治疗终止时间为出现疾病进展(PD),患者死亡或不可耐受的毒性。主要观察指标是肿瘤反应率(ORR),完全缓解(CR)、部分缓解(PR),稳定(SD)和进展(PD),ORR=CR+PR。结果:对照组ORR为36.3%,试验组为ORR为45.6%,两组之间差异有统计学意义(χ2=3.046,P=0.032)。药物毒性发生率方面,在腹泻、恶心/呕吐和虚弱发生率方面,对照组明显高于试验组(χ2=9.156,P=0.016;χ2=10.047,P=0.035;χ2=9.530,P=0.002)。结论:消癌平注射液联合XELOX方案治疗晚期胃癌临床效果较好,无严重的不良反应,并且在一定程度上可减轻化疗所致的消化道反应及虚弱乏力的发生率,安全性高,对治疗晚期胃癌有较好的前景。Objective： To investigate the clinical effect of xiaoaiping injection combined with XELOX regimenin the treatment of advanced gastric cancer. Methods ： 183 cases of patients with advanced gastric cancer from 2008 June to 2012 June in our hospital diagnosed, with odd and even number of randomizing method, 183 patients were randomly divided in- to experimental group 92 cases, control group 91 cases, two groups of subjects were treated with oxaliplatin 135mg/square meters, intravenous drip, once every three Monday, 2500mg/square meters of Xeloda/day, 14 day oral chemotherapy, chemotherapy for at least two cycles. The test group withxiaoaiping injection 40ml/d, intravenous drip for 14 days. In this study, treatment of the termination time to disease progression （PD） , the patient dies or intolerable toxicity. Main outcome measures is tumor response rate （ORR） , complete remission （CR） , partial remission（PR） , stability （SD） and progress （PD）, ORR = CR ten PR. Results： In the control group, ORR was 36.3%, the test group for the ORR is 45.6% , the difference was statistically significant between the two groups （ X2 = 3. 046, P = 0.032）. Drug toxicity oc- curred in the control group the incidence, diarrhea, nausea / vomiting and weakness, the incidence was significantly higher than the control group, the experimental group （X2 = 9. 156,P = 0.016 ;X2 = 10. 047,P = 0. 035 ; X2 = 9： 530,P = 0. 002） . Conclusion ： The better clinical effect of xiaoaiping injection combined with XELOX regimen in the treatment of advanced gastric cancer,no serious adverse reaction and toxicity inhibition and to some extent alleviate chemotherapy- department refers to the bone marrow, high safety, has good prospects in the treatment ofadvanced gastric cancer.

关 键 词：消癌平注射液 奥沙利铂 希罗达 晚期胃癌 效果分析 

分 类 号：R735.2[医药卫生—肿瘤]