细胞因子诱导的杀伤细胞联合化疗对比单纯化疗治疗中晚期胃癌的Meta分析  

A meta-analysis of cytokine-induced killer cells therapy in combination with chemotherapy for intermediate and advanced gastric cancer

作　　者：屈涛[1] 杨林[1] 张弘纲[1] 崔成旭[1] 

机构地区：[1]中国医学科学院肿瘤医院内科,北京100021

出　　处：《中国医刊》2015年第4期49-53,共5页Chinese Journal of Medicine

摘　　要：目的：评价细胞因子诱导的杀伤细胞（ cytokine-induced killer cells,CIK）治疗联合化疗对比单纯化疗治疗中晚期胃癌的有效性。方法检索PubMed、中国知网中文数据库、中国生物医学文献数据库和万方中文数据库,检索时限为数据库建库至2014年6月,筛选关于CIK联合化疗对比单纯化疗治疗中晚期胃癌相关的病例对照研究或队列研究,使用RevMan5.3和Stata11.2进行统计分析。结果共纳入5篇文献, Meta分析显示,部分缓解部分[OR=2.14,95%置信区间（confidence interval,CI）=1.17~3.89]及完全进展部分（OR=0.53,95%CI=0.29~0.95）两种方案差异有显著性。2年生存率（OR=1.93,95%CI=1.13~3.30）及5年生存率（OR=2.18,95%CI=1.09~4.13）CIK联合治疗方案显著优于单纯化疗方案,差异具有显著性。结论 CIK联合化疗较单纯化疗治疗中晚期胃癌具有优势。Objective To evaluate the results of CIK cells transfusion therapy combined with chemotherapy over chemo-therapy alone for intermediate and advanced gastric cancer. Method According to the integration and elimination stand-ard,the cases evaluated the results of CIK cells transfusion therapy combined with chemotherapy over chemotherapy alone for intermediate and advanced gastric cancer were strictly selected,retrieving database dated to June 2014 collected via searching database including Pubmed,CNKI,CBM and Wanfang database. RevMan5. 3 and Stata11. 2softwares were used for statistical analysis. Result A total of 5 good studies were included in the meta-analysis. The results of meta-analysis showed that CIK cells transfusion therapy combined with chemotherapy was associated with more PRs（OR=2. 14,95% CI=1. 17~3. 89） and less PSs（OR=0. 53,95% CI=0. 29~0. 95） than chemotherapy alone. Meanwhile,2-year overall rate （OR=1. 93,95% CI=1. 13~3. 30） and 5-year overall rate（OR=2. 18,95%CI=1. 09~4. 13） for combination therapy were higher than chemotherapy alone. Conclusion The result of meta-analysis suggests that CIK cells transfusion therapy combined with chemotherapy for intermediate and advanced gastric cancer has some distinct advantages over chemotherapy alone. Further studies are needed to validate the conclusion.

关 键 词：胃癌 细胞因子诱导的杀伤细胞治疗 化疗 生存 META分析 

分 类 号：R735.2[医药卫生—肿瘤]