乳腺颗粒细胞瘤的临床病理观察  

Clinical pathology observation of breast granular cell tumor

作　　者：豆颖[1] 闫哲[2] 

机构地区：[1]商丘市第一人民医院病理科,476000 [2]商丘市第一人民医院心血管内科,476000

出　　处：《中国实用医药》2015年第8期8-10,共3页China Practical Medicine

摘　　要：目的探讨发生于乳腺的颗粒细胞瘤患者的临床病理学特征、免疫表型、鉴别诊断及预后。方法收集2例发生于乳腺的颗粒细胞瘤患者的临床和病理资料,对其大体改变、组织形态和免疫表型进行回顾性分析,并复习文献和总结。结果 2例均为女性,镜下瘤细胞境界清晰,胞质丰富,胞体宽大,内充满大量嗜酸性颗粒,呈浸润性生长。免疫组化S-100、CD68、神经特异性烯醇化酶(NSE)、波形蛋白(Vimentin)阳性表达,而细胞角蛋白(CK)、上皮膜抗原(EMA)、平滑肌肌动蛋白(SMA)阴性表达,Ki-67增殖指数<1%。结论乳腺颗粒细胞瘤较为少见,绝大部分为良性,临床及术中快速易误诊为癌,应提高对该疾病的认识,减少过度手术风险。Objective To explore the clinicopathologic features, immunophenotype, differential diagnosis, and prognosis of breast granular cell tumor. Methods Clinical and pathological data of 2 patients with breast granular cell tumor were collected, and their general change, tissue form, and immunophenotype were retrospectively analyzed. Related document and summary were reviewed. Results These two cases were female, and t heir tumor cell showed clear boundary, abundant cytoplasm, wide soma with plenty of eosinophilic granular, and infiltrative growth. The immunohistochemistry S-100, CD68, neuron specific enolase（NSE）, and Vimentin had positive expressions, and cytokeratin（CK）, epithelial membrane antigen（EMA）, and smooth muscle actin（SMA） had negative expressions. The proliferation index of Ki-67 was 1%. Conclusion Breast granular cell tumor is rare, and most of it is benign. It can be easily misdiagnosed as cancer in clinic and operation. The understanding of this disease should be enhanced to reduce risk of excessive operation.

关 键 词：颗粒细胞瘤 乳腺肿瘤 临床 病理 

分 类 号：R737.9[医药卫生—肿瘤]