GFL方案治疗FOLFOX方案失败胃癌的临床观察  

Clinical observation of GFL regimen in the treatment of gastric carcinoma with failed FOLFLX regimen

作　　者：江丹贤[1] 翁一洁[1] 梁彩霞[1] 庞雅君[1] 陈国强[1] 

机构地区：[1]广东医学院附属医院肿瘤中心,524001

出　　处：《中国实用医药》2015年第8期28-30,共3页China Practical Medicine

摘　　要：目的观察GFL方案（吉西他滨＋5-氟尿嘧啶/亚叶酸钙）治疗FOLFOX方案（草酸铂＋5-氟尿嘧啶/亚叶酸钙）失败晚期胃癌的疗效和不良反应。方法 27例FOLFOX方案失败的晚期胃癌患者,应用GFL方案治疗2～4个周期。观察疗效。结果 27例均可评价,有效率为33.3%,其中完全缓解0例（0）,部分缓解9例（33.3%）,稳定11例（40.7%）,进展7例（25.9%）,中位生存期5.2个月。不良反应主要为恶心呕吐、腹泻、骨髓抑制和肝功能损害,但均为轻度。结论 GFL方案治疗FOLFOX方案失败的晚期胃癌有一定疗效,不良反应可耐受,值得临床推广应用。Objective To observe the curative effect and adverse reactions of GFL regimen（gemcitabine＋5-fluorouracil/calcium folinate） in the treatment of advanced gastric carcinoma with failed FOLFLX regimen（oxaliplatin＋5-fluorouracil/calcium folinate）. Methods There were 27 patients with advanced gastric carcinoma received failed FOLFOX regimen, and they all received GFL regimen for treatment for 2～4 period. Curative effect was observed. Results All the 27 cases could be evaluated, and their effective rate was 33.3%. There were 0 case of complete remission（0）, 9 cases of partial remission（33.3%）, 11 stable cases（40.7%）, and 7 progressed cases（25.9%）. The median survival time was 5.2 months. The main adverse reactions included nausea and emesis, diarrhea, myelosuppression, and liver function damage all at mild stage. Conclusion GFL regimen in the treatment of advanced gastric carcinoma with failed FOLFOX regimen has a certain effect and tolerable adverse reactions, and it is worthy of clinical promotion and application.

关 键 词：胃癌 吉西他滨 5-氟尿嘧啶 亚叶酸钙 

分 类 号：R735.2[医药卫生—肿瘤]