地佐辛对宫颈癌手术患者全麻恢复期BIS及苏醒质量影响的研究  

Effect of dezocine on BIS and recovery quality during the anesthesia emergence period in the cervical cancer surgery

作　　者：张娇[1] 

机构地区：[1]海南医学院附属医院麻醉科,海南海口570102

出　　处：《海南医学院学报》2015年第6期775-777,共3页Journal of Hainan Medical University

摘　　要：目的:研究地佐辛对宫颈癌手术患者全麻恢复期脑电双频指数(BIS)和苏醒质量的影响。方法:将本院收治的80例行宫颈癌手术的患者随机分为A组与B组,每组40例;A组为对照组,在手术前20min给予生理盐水5mL,B组为实验组,给予地佐辛0.1mg/kg。记录A、B两组术前(T0)、气管插管时(T1)、气管拔管后1min(T2)、5min(T3)、10min(T4)的BIS、MAP、HR和SpO2值,以及睁眼时间、定向力恢复时间、芬太尼用量、VAS评分以及躁动情况。结果:两组在各时间点的BIS、SpO2比较,差异均无统计学意义(P>0.05);与T0时刻相比,两组BIS其它各时刻均明显降低;A组各时刻与T0时刻相比,MAP值明显升高,HR明显加快,差异具有统计学意义(P<0.05);B组与A组相比较,各时刻与T0时刻相比,MAP值明显降低,HR明显减慢,差异具有统计学意义(P<0.05);A组睁眼时间、定向力恢复时间较B组长、A组VAS评分较B组高,差异具有统计学意义(P<0.05);两组躁动情况比较,差异无统计学意义(P>0.05)。结论:宫颈癌手术中使用0.1 mg/kg的地佐辛对手术患者全麻恢复期BIS无影响,且提高苏醒质量。Objective： To explore the effects of dezocine on BIS and recovery quality during the anesthesia emergence pe- riod in the cervical cancer surgery. Methods： Eighty patients scheduled for cervical cancer surgery treated in our hospital were randomly divided into group A and group B with 40 cases in each group. Group A was given 5 mL saline 20 min before the sur- gery started. Group B was given 0.1 mg/kg Dezocine 0. 1 mg/kg. Recorded and compared the BIS, MAP, HR and SpO2 at preoperative（T0 ）, intubation（T1 ）, 1 rain after extubation（T2 ）, 5 min after extubation（T3）, 10 rain after extubation（T4 ）and opening eyes time, orientation recovery time, the dosage of consumed Fentanyl, VAS score and restlessness between two groups were compared. Fiesults： There was no significant difference in BIS and SpO2 between group A and group B at different time points （P〉0.05）. Comparing with To ,the BIS at other time points were significant lower in two groups. In group A, the MAP at other time points were significant higher and HR were faster than that at To （P〈0.05）. In group B,the MAP at other time were lower and the HR were slower（P〈0.05）. The opening eyes time and orientation recovery time of group A were lon- ger than that of group B（P〈0.05）. The VAS score of group A was higher than that of group B（P〈0.05）. There was no sta-tistieal difference in restlessness （P〉0. 05）. Conclusion： Oezocine at the dosage of 0. 1 mg/kg have no effects on BIS but it can increase recovery quality during the anesthesia emergence period.

关 键 词：地佐辛 宫颈癌 脑电双频指数(BIS) 苏醒质量 

分 类 号：R737.33[医药卫生—肿瘤]