血脂代谢与年龄相关性黄斑变性的关联研究  

Association of serum lipids with age-related macular degeneration

作　　者：李佳玙 李慧萍 盛迅伦 李武靓 白蓉[1] 

机构地区：[1]宁夏医科大学,宁夏银川750004 [2]宁夏人民医院眼科医院,宁夏银川750001

出　　处：《宁夏医学杂志》2015年第5期385-388,共4页Ningxia Medical Journal

基　　金：国家重点基础研究发展计划(973课题;2011CB510200);宁夏卫生厅重点科研计划课题(2011011);宁夏自然科学基金资助项目(NZ11163)

摘　　要：目的探索血脂及危险因素、疾病等与年龄相关性黄斑变性（AMD）的关联关系。方法采用病例对照研究设计,共纳入AMD组100例,对照组147例。收集年龄、性别、疾病史及吸烟、饮酒等行为因素,通过抽血测定血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL）、低密度值蛋白胆固醇（LDL）、载脂蛋白A1（Apo A1）、载脂蛋白B（Apo B）水平,使用秩和检验、χ2检验及多因素logistic分析数据。结果结果显示吸烟、高血压及高血脂、Apo A1、Apo B在病例组及对照组之间差异有统计学意义（P〈0.05）;饮酒、冠心病病史与AMD之间无相关性（P〉0.05）。高血脂、Apo A1在AMD病人回汉民族之间及各分期之间差异无统计学意义（P〉0.05）;Apo B在病例组的回汉族差异有统计学意义（P〈0.05）,而在AMD各分期间差异无统计学意义（P〈0.05）。多因素Logistic分析显示,吸烟（OR=2.7,P〈0.05,95%CI：1.251~5.874）、高血压（OR=2.8,P〈0.05,95%CI：1.476~5.373）、高血脂（OR=2.02,P〈0.05,95%CI：1.115~3.655）及Apo A1（OR=0.09,P〈0.05,95%CI：0.011~0.743）与AMD发病风险有相关性,而Apo B与AMD无相关性（OR=1.55,P〉0.05,95%CI：0.603~3.975）。结论吸烟、高血压及高血脂、Apo B是AMD的危险因素,Apo A1是保护性因素。高血脂及Apo A1在AMD病人回汉族及各分期之间无显著差异,回族人群较汉族人群Apo B升高的个体少。Objective To explore the relationship between serum lipids,environmental risk factors,disease and age- related macular degeneration（ AMD） in order to provide the basis for prevention,treatment and prognosis of AMD. Methods In this case- control study,100 AMD cases and 147 controls were selected. Information of age,sex,diseases history,smoking,drinking of two groups was collected. Peripheral blood sample was obtained from each person. Serum concentration of total cholesterol（ TC）,triglycerides（ TG）,high- density lipoprotein cholesterol ester（ HDL）,low- density lipoprotein cholesterol ester（ LDL）,apolipoprotein A1（ Apo A1）,apolipoprotein B（Apo B） were examined. Data were analyzed by using rank- sum test. Results There were significant differences in smoking（P〈0. 05）,hypertension（ P〈0. 05）,hyperlipemia（ P〈0. 05）,Apo A1（ P〈0. 05） and Apo B（ P〈0. 05） between case and control group. Alcohol drinking and coronary heart disease showed no association with AMD（ P〉0. 05）. Hyperlipemia and Apo A1 of Han group had no association with that of Hui group（ P〉0. 05）. There were also no significant difference in hyperlipemia,Apo A1 between two stages of AMD patients（ P〉0. 05）. Apo B serum level were higher in Han group than that in Hui group（ P〈0. 05）,but there was no difference in Apo B level between two stages of AMD. When multiple risk factors were considered simultaneously in the logistic regression analyses,only smoking（OR =2. 7,P =0. 011,95% CI：1. 251 ~5. 874）,hypertension（OR =2. 8,P〈0. 05,95% CI：1. 476 ~ 5. 373）,hyperlipemia（OR = 2. 02,P〈0. 05,95% CI：1. 115 ~ 3. 655） showed an increasing odds ratio with AMD. While Apo A1（ OR = 0. 09,P〈0. 05,95% CI： 0. 011 ~0. 743） showed an decreasing odds ratio with AMD. Conclusion Smoking,hypertension,hyperlipemia and Apo B are associated with increased risk of AMD,while Apo A1 shows protective to AMD. Hyperlipemia and Apo A1 of Han group have no association with that of Hui grou

关 键 词：年龄相关性黄斑变性 危险因素 血脂 

分 类 号：R774.5[医药卫生—眼科]