通过Fas／FasL途径诱导肿瘤细胞凋亡的天然黄酮和生物碱类化学成分研究进展  

Advances in Research on Fas/FasL Cell Signal Transduction Pathway Inducing Tumor Cell Apoptosis by Natural Flavonoids and Alkaloids Chemical Constituents

作　　者：杨珞[1,2] 陈康柳 冯洁[1] 莫书荣[2] 

机构地区：[1]广西医科大学药学院 [2]广西医科大学基础医学院,南宁530021

出　　处：《天然产物研究与开发》2014年第A02期327-331,共5页Natural Product Research and Development

基　　金：广西自然科学基金（2010GXNSFA013187）

摘　　要：天然药物因其作用广、疗效好、毒副作用小等特点及现代人回归自然的心态而成为抗肿瘤药物研究的热点。早期的化学家或天然药物研究人员对化学或天然产物的研究多半局限在普通的药理活性筛选，随着科学技术的进步，学科之间的交叉渗透发展，对天然抗肿瘤药物或天然活性成分抗肿瘤作用机理的研究不断深入，许多抗肿瘤药物或活性化学成分的作用靶点、作用通路等得以阐述，其中Fas及其配体FasL是近年来研究最为深入的有关细胞凋亡的膜表面分子。大量研究发现许多天然药物可增加肿瘤细胞Fas的表达，启动Fas／FasL途径，从而起到诱导肿瘤细胞调亡的作用。黄酮和生物碱类为天然产物中分布广泛、研究深入和生物活性显著的两种类型化合物，为了更深入地研究这两种类型的化合物，现将通过Fas／FasL途径诱导肿瘤细胞凋亡的天然黄酮和生物碱类化学成分作一文献综述，旨在为这两类成分的抗肿瘤活性及其机理的深入研究提供参考。Natural medicine becomes the research hotspet of antitumor drugs for the characteristics of extensive effects, good curative effects and small toxic and side effects, and modernists＇ psychology of returning to nature. In the early time, most of the research of which on chemical or natural products by chemists or natural medicine researchers were limited to the normal pharmacological activity screening. With the advance of science and technology, there is development crossed and permeated among different subjects, and research on the anti-tumoi action mechanism of natural antitumor drugs and natural activity anti-tumor effect can be further explored constantly ,the action target spot and pathways on a lot of anti-tumor drugs or activity chemical compositions can be elaborated. Besides, Fas and Ligand FasL are mem- brane molecules related to cell apeptesis which are studied very intensively in recent years. It＇ s found through a lot of studies that a number of natural medicines can strengthen Fas expression of tumor cells and start Fas/Fasl pathways so as to have the effect of inducing tumor cell apoptosis. Flavone and alkaloids are chemical compounds are extensively distributed, studied deeply and have significant biological activity in natural products. In order to further study these two chemical compounds, natural flavone and alkaloids are used to induce tumor cell apoptosis through Fas/FasL pathway as the literature review,the purpose of which is to offer reference for the further study on the antitumor activity and mechanisms of these two compositions.

关 键 词：细胞凋亡Fas/FasL 黄酮 生物碱 新药研发 

分 类 号：R-1[医药卫生]