Alginate-Coated Fe3O4 Hollow Microspheres for Drug Delivery  

海藻酸改性的空心Fe304纳米颗粒的制备与应用

作　　者：董丽娟[1] 金谷[2] 

机构地区：[1]浙江工商大学食品科学与生物技术学院,杭州310018 [2]中国科学技术大学化学系,合肥230026

出　　处：《Chinese Journal of Chemical Physics》2015年第2期193-196,I0002,共5页化学物理学报（英文）

摘　　要：Novel hollow Fe3O4 nanoparticles for drug delivery were synthesized via a one-step template- free approach. These nanoparticles were obtained by modifing the Fe3O4 nanoparticles with 3-aminopropyltrimethoxy silane, and then grafting alginate onto the surface of amine magnetic. The hollow structure of Fe3O4 spheres was characterized by TEM, XRD, and XPS. The M-H hysteresis loop indicated that the magnetic spheres exhibit snperparamagnetic characteristics at room temperature. Daunorubicin acting as a model drug was loaded into the carrier, and the maximum percent of envelop and load were 28.4% and 14.2% respectively. The drug controlled releasing behaviors of the carriers were compared in different pH media.

关 键 词：Hollow Fe3O4 nanoparticles 3-Aminopropyltrimethoxy silane Drug delivery 

分 类 号：O[理学]