用于光学相干层析成像设备点扩散函数测量的模体制作与使用方法研究  

Research on Point Spread Function Phantom Fabrication and Application for Evaluating Resolution Performance of OCT Systems

作　　者：胡志雄[1] 郝冰涛[1] 刘文丽[1] 洪宝玉[1] 

机构地区：[1]中国计量科学研究院医学与生物计量研究所,北京100029

出　　处：《光学学报》2015年第4期273-279,共7页Acta Optica Sinica

基　　金：国家科技支撑计划(2011BAI02B02)

摘　　要：点扩散函数一般用于成像光学系统的分辨率评价,而掺杂微球的模体经常被用于获取光学相干层析成像(OCT)系统的点扩散函数。采用一种简单快速的基于表面硅烷化处理的加工工艺,制作出掺杂直径为1μm聚苯乙烯微球的聚二甲基硅氧烷(PDMS)点扩散函数模体,该工艺无需任何打磨与抛光即可得到光洁度优良的模体表面。使用一台谱域OCT系统对该模体进行检测,通过处理OCT图像得到点扩散函数并计算得到OCT系统的轴向与横向分辨率,分别为6.8 mm和14.3 mm,与理论预测值十分接近,证明了点扩散函数模体评价方法的有效性。Microsphere embedded phantoms are widely used to characterize point spread functions（PSF）, which are generally employed to evaluate resolution performance of optical imaging systems such as optical coherence tomography（OCT）. A convenient method based on surface silanization of silicon wafer is employed to prepare point spread function phantoms by mixing 1 μm in diamter polystyrene microspheres with transparent polymer-polydimethylsiloxane（PDMS）. Compared to conventional methods employing moulding and polishing, the rapid prototyping process based on PDMS provides a faster, less expensive alternative. Detailed fabrication procedures as well as specific designs are described, and the produced PSF phantoms are utilized for performance assessment of a spectral domain OCT system. By analyzing the point spread functions, 6.8 mm axial resolution and 14.3 mm lateral resolution are obtained and in good agreement with the theoretically predicted values. For comparison,images of the standard-size microspheres are provided by measuring the PSF phantoms with optical microscope.

关 键 词：医用光学 模体 点扩散函数 光学相干层析 分辨率 

分 类 号：TN247[电子电信—物理电子学] O439[机械工程—光学工程]