抑郁症患者应用无抽搐电休克治疗对患者血清脑源性神经营养因子的影响  

Analysis of serum brain-derived neurotrophic factors for patients with depression treated with therapy without seizure electroconvulsive

作　　者：张晓莉[1] 代中全 范红[2] 

机构地区：[1]四川遂宁市中心医院心理咨询科,遂宁629000 [2]四川遂宁市民康医院,遂宁629000

出　　处：《中国实用神经疾病杂志》2015年第6期22-24,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的分析抑郁症患者应用无抽搐电休克治疗对患者血清脑源性神经营养因子的影响。方法将160例抑郁症患者按照入院先后顺序依次编号,采用数字随机表法分组,单号为研究组,双号为对照组。对照组采用艾司西酞普兰治疗;研究组采用艾司西酞普兰联合无抽搐电休克治疗。结果治疗前,2组患者BDNF水平比较无显著差异(P>0.05);治疗后,2组患者均出现明显升高,与治疗前比较差异有统计学意义(P<0.05);但研究组优于对照组(P<0.05)。研究组治疗有效率为92.50%(74/80)与对照组82.50%(66/80)比较差异有统计学意义(P<0.05)。同时2组患者治疗前后HAMD、HAMA及CGI、认知功能均得到明显改善(P<0.05)。此外,2组患者均未发生性功能障碍等不良反应。结论采用无抽搐电休克治疗抑郁症,有效改善患者抑郁、焦虑及认知功能,提高患者BDNF水平,对患者性功能无影响,是一种安全有效的治疗方式,值得推广应用。Objective To investigate the effect of serum brain-derived neurotrophic factors for patients with depression treated with therapy without seizure electroconvulsive. Methods 160 cases with depression were classified by random number table method based on sequence number of hospital admission ,odd-numbered cases were regarded as study group receiving therapy of seizure electroconvulsive and escitalopram ,while even-numbered cases as control group with escitalopram treat-ment.Results BDNF levels ,HAMD scores ,HAMA scores ,CGI scores and cognitive function in two groups after treatment were significantly higher than that before therapy （P〈0.05） ,which had no difference in two groups before treatment（P〉0.05）. The effective rate with 92.50% in study group was prior to 82.50% in control group （P〈0.05）. In addition ,cases in two groups had no adverse reactions such as sexual dysfunction. Conclusion Adopting therapy without seizure electroconvul-sive in patients with depression can effectively improve cognitive function ,considered as a safe and effective treatment ,which should be widely applied.

关 键 词：抑郁症 血清脑源性神经营养因子 无抽搐电休克 

分 类 号：R749.41[医药卫生—神经病学与精神病学]