仙灵骨葆对犬种植体周围炎龈沟液中IL-1、IL-6含量影响实验分析  

Effects of Xianling Gubao on IL-1 IL-6 in Peri-implant Sulcular Fluid of Experimental Peri-implantitis

作　　者：董滢[1] 蒋柳宏[2] 闫春歌[2] 

机构地区：[1]广州中医药大学祈福医院,广东广州511495 [2]广州中医药大学第一附属医院,广东广州510405

出　　处：《辽宁中医药大学学报》2015年第5期38-40,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：广东省中医药管理局建设中医药强省课题(20131235)

摘　　要：目的:观察仙灵骨葆对犬种植体周围炎龈沟液中白细胞介素-1(IL-1)、白细胞介素-6(IL-6)含量的影响,以此评判仙灵骨葆对种植体周围炎的治疗作用。方法:把参与犬分为对照组、实验组,将实验组建立种植体周围炎模型,而后实验组再随机分为中药组和盐水组,各组均于给药时(基点)和基点后1、4、8、12、16周采集种植体周围龈沟液,并测定IL-1、IL-6含量。结果:(1)实验组菌斑指数、探诊深度、牙龈指数均明显高于对照组,差异具有显著性意义(P<0.01),成功复制犬种植体周围炎动物模型;(2)中药组龈沟液中IL-1、IL-6含量于8周开始显著下降,到16周时同对照组相比无明显差异(P>0.01),盐水组龈沟液中IL-1、IL-6含量始终处于较高水平,同对照组有明显差异(P<0.01)。结论:仙灵骨葆可以有效的降低犬种植体周围炎龈沟液中IL-1、IL-6的表达,达到治疗的目的。Objective：To investigate the effects of Xianling Guhao on IL-1, IL-6 in peri-implant sulcular fluid of experimental peri-implantitis. Methods ： The animal models of of dogs were established by silk ligation. They were randomly divided into 2 groups ： the Xianling Gubao group and salt water group. The dogs without peri-implantitits were＇regarded as control group. PISF samples were collected using a filter paper technique. The levels of IL-1 and IL-6 in PISF were assessed using commercially available enzymelinked immunosorbent assay kits at 1,4,8,12,16 weeks after having medicine. Results： （ 1 ）After silk ligation, PI, PD and GI significantly changed. （ 2 ） The levels of in PISF of Xianling Gubao group decreased significantly after 8 weeks, and after 16 weeks, the Xianling Gubao group and control group had the same level of IL-1 and IL-6. Conclusion ： Xianling Gubao can decrease significantly the level of IL-1 and IL-6 in peri-implant suleular fluid of experimental peri-implantitis.

关 键 词：仙灵骨葆 种植体周围炎 龈沟液 白细胞介素-1 白细胞介素-6 

分 类 号：R781.4[医药卫生—口腔医学]