多模微波辅助的聚乙二醇化聚苯乙烯树脂制备  

Multi-mode microwave assisted preparation of PEGylated polystyrene resin

作　　者：王刚[1,2] 彭涛[2] 张首国[2] 王君逸 温晓雪[2] 颜海燕[2] 胡利明[1] 王林[1,2] 

机构地区：[1]北京工业大学生命科学与生物工程学院,北京100022 [2]军事医学科学院放射与辐射医学研究所,北京100850 [3]北京大学基础医学部,北京100191

出　　处：《国际药学研究杂志》2015年第2期210-214,219,共6页Journal of International Pharmaceutical Research

基　　金：国家自然科学基金资助项目(81273431,81072531,30770655,21272273)

摘　　要：目的研究一种微波辅助的聚苯乙烯树脂聚乙二醇(PEG)化的方法。方法使用PEG 200对市售Merrifield树脂进行修饰,尝试了不同条件下PEG化的效率。使用自行制备的PEG化树脂进一步衍生化,并进行氨基酸的负载,与市售王树脂进行比对。结果优选出了一套较为合适的反应参数,使用5 g树脂,50 ml PEG 200,微波功率600 W,预设温度170℃,照射15 min,共2次,获得了接近90%的负载率。衍生化得到PEG化王树脂后与氨基酸进行缩合,获得了令人满意的产率。结论本文首次报道了多模微波装置辅助的聚苯乙烯树脂PEG化,该方法操作简单,制备快速,条件温和,产率满意,远远优于传统制备方法。Objective To study a method of microwave-assistant PEGylation of polystyrene resin. Methods Modify the commercial Merrifield resin with PEG-200,and study the influence of the yield under different conditions. The self-prepared PEG resin was further derived to PEG-wang resin;kinds of amino acids were anchored,and the loading rates were compared with commercial wang resin. Result A general series react conditions were preferred,which was performed with 5 g resin,50 ml PEG-200,irradiating for 15 min×2 at 600 W,preset temperature was 170 ℃. The resin was then transformed to PEGylated Wang resin and anchored with amino acids,the yields were satisfied. Conclusion The multi-mode microwave assistant PEGylation of Merrifield resin method was first reported in this paper. This method has the advantages of simple operation,fast preparation,mild reaction conditions and good yield,which was much better than the traditional method.

关 键 词：多模微波辅助 聚乙二醇化 聚苯乙烯树脂 

分 类 号：TQ325.2[化学工程—合成树脂塑料工业]