软骨母细胞瘤20例临床病理分析  

Clinicopathological analysis of 20 cases of chondroblastoma

作　　者：罗华[1] 肖秀丽[1] 蒋堃[1] 杨志惠[1] 

机构地区：[1]泸州医学院附属医院病理科,四川泸州646000

出　　处：《泸州医学院学报》2015年第2期119-123,共5页Journal of Luzhou Medical College

基　　金：国家自然科学基金资助项目(81101679)

摘　　要：目的:探讨软骨母细胞瘤的临床、影像学、病理形态学和免疫组化特征,明确病理诊断及鉴别诊断。方法:收集我院1998年至2014年经病理证实的20例软骨母细胞瘤,用HE和免疫组化方法进行病理学观察,同时分析其临床和影像学特点。结果:20例患者中男性13例,女性7例,多发于青少年,平均年龄17岁,>20岁者4例。最常见的部位是长骨(75%),尤其是股骨、胫骨和肱骨,其他部位5例。X线通常表现为骨骺或骨突部位圆形或卵圆形地图状溶骨性骨质破坏,边界清楚,常有薄层边缘硬化,破坏区常见细小的斑点状钙化或骨化阴影,很少膨胀性改变和骨膜反应。1例有局部骨皮质破坏合并动脉瘤样骨囊肿。镜下软骨母细胞瘤由增生的软骨母细胞、粉红色软骨样基质及散在破骨样巨细胞组成,"窗格样钙化"和免疫组化软骨母细胞S-100(+)对正确诊断十分重要。结论:掌握软骨母细胞瘤的临床、影像学、病理形态和免疫组化特征,对软骨母细胞瘤的病理诊断及鉴别诊断具有重要意义。Objective： To study the clinical, patho morphologic, radiographic and immunohistochemical characteristics of chondroblastoma for pathological diagnosis and antidiastole. Methods： 20 patients with chondroblastoma from 1998 to 2014 were retrospectively reviewed. Hematoxylin eosin （HE） staining and immunohistochemical （IHC） staining were applied. Radiographic and clinical were characteristics were reviewed. Results： The disease occurred predominantly in adolescents （mean age 17, 4 cases 〉 20）, more common in males （13 men and 7 women）. The common location was long bone, particularly tibia, femur and humerus, only 5 cases occurred in other bones. X- ray showed circular or ovoid, expanded, lyric lesion in the epiphysis of bone, often containing irregular calcifications, mostly without periosteal reaction. The lesion usually had a thin sclerotic border. Chondroblastoma with aneurysmal bone cyst occurred in one case. Microscopically, the characteristic findings was abundance of immature eosinophilical chondroid matrixes, hypercellularity of the chondroblasts, and chicken-wire-like＇calcifications. Immunohistochemically, the positive expression of S-100 protein was helpful for correct diagnosis. Conclusions： Understanding of the characteristics of clinicpathology, radiographs, and immunohistochemical markers on chondroblastoma is essential for diagnosis and differential diagnosis of chondroblastoma.

关 键 词：软骨母细胞瘤 病理诊断 免疫组化 鉴别诊断 

分 类 号：R738.3[医药卫生—肿瘤]