卵巢成熟性畸胎瘤伴甲状腺肿类癌1例及文献复习  

Ovarian mature cystic teratoma accompanied with strumal carcinoid: a case report and literature review

作　　者：夏天[1] 肖秀丽[1] 周铁军[1] 罗华[1] 

机构地区：[1]泸州医学院附属医院病理学科,四川泸州646000

出　　处：《泸州医学院学报》2015年第2期139-141,共3页Journal of Luzhou Medical College

基　　金：泸州市科技计划项目;项目编号(2013-S-47)

摘　　要：目的:探讨1例卵巢成熟性畸胎瘤伴甲状腺肿类癌的临床病理特征。方法:对1例诊断为卵巢成熟性畸胎瘤伴甲状腺肿类癌患者的临床资料、组织学形态及免疫组化结果进行分析,并对相关文献进行复习。结果:本例为卵巢成熟性畸胎瘤伴甲状腺肿类癌,病理学检查除成熟性畸胎瘤成分外,另见由甲状腺和类癌组织混合成的结节一枚,类癌细胞较小且大小相仿,染色质均匀,核分裂少见,免疫组化:甲状腺滤泡上皮细胞TG(+)、TTF-1(+),类癌细胞CD99(+)、Cg A(+)、Syn(+)、CK7(-)。结论:卵巢成熟性畸胎瘤伴甲状腺肿类癌为罕见的病变,临床患者多无典型症状,且类癌成分多与甲状腺组织混杂于畸胎瘤中,容易漏诊,故应广泛取材并提高对卵巢成熟性畸胎瘤伴甲状腺肿类癌组织学特征及免疫表型的认识,对累积资料,避免临床误诊、漏诊具有重要的价值。Objective： To discuss the clinicopathologic features of ovarian mature cystic teratoma with strumal carcinoid. Methods： Clinical data,pathological diagnosis and immunohistochemical results of a case of ovarian mature cystic teratoma with strumal carcinoid were analyzed,and related literatures were reviewed. Results： This case was an ovarian mature cystic teratoma, histopathological examination revealed a nodule of strumal carcinoid. It mainly consisted of unequal-sized thyriod follicle and carcinoid cells. Thyriod follicle epithelial cells were positive for TG and TTF-1 and carcinoid cells were positive for CD99, CgA, Syn, but nagtive for CK7. Conclusions： Ovarian mature cystic teratoma with strumal carcinoid is a rare disease. It usually lack of typical clinical symptom and carcinoid cells always mix with thyriod tissue. It is easilly misdiagnosed. Therefore careful gross examination, extensive sampling and immunohistochemical exam are very important for its correct diagnosis.

关 键 词：卵巢甲状腺肿类癌 畸胎瘤 病理特征 

分 类 号：R361.2[医药卫生—病理学] R365[医药卫生—基础医学]