乳腺癌患者治疗前后测定血清甲状腺激素、CA153和高敏C-反应蛋白水平的临床价值  

The clinical value of determining serum thyroid hormone, CA153 and high-sensitive C-reactive protein in patients with breast cancer

作　　者：徐建红[1] 钮丽萍[1] 

机构地区：[1]南通大学附属吴江医院检验科,吴江215200

出　　处：《南通大学学报（医学版）》2015年第2期126-129,共4页Journal of Nantong University(Medical sciences)

摘　　要：目的：探讨乳腺癌患者治疗前后测定甲状腺激素（thyroid hormone, TH），CA153和高敏C-反应蛋白（high-sensitive C-reactive protein, hs-CRP）水平的临床价值。方法：采用化学发光免疫分析和免疫比浊定量法测定了156例乳腺癌患者治疗前后和60例正常对照组血清TH，包括3,3’,5-三碘-L-甲腺原氨酸[O-（4-Hydroxy-3-iodophenyl）-3,5-di-iodo-L-tyrosine, T3]、游离型T3（free T3， FT3）、L-甲状腺素（L-thyroxine, T4）、游离型 T4（free T4， FT4）和促甲状腺激素（thyroid stimulating hormone, TSH）, CA153和hs-CRP水平，进行了对比性分析。结果：在治疗前，乳腺癌患者血清T3和FT3水平较正常对照组明显降低（均P〈0.01），并随乳腺癌Ⅰ~Ⅳ期严重程度的增加而降低；血清FT4水平降低（P〈0.05）。血清T4和TSH水平差异无统计学意义（均P＞0.05）；血清CA153和hs-CRP水平较正常对照组明显增高（均P〈0.01），且随乳腺癌严重程度的增加而增高。乳腺癌患者治疗后，Ⅰ、Ⅱ期患者血清T3和FT3水平恢复至正常水平，CA153和hs-CRP为正常水平（均P＞0.05）；Ⅲ、Ⅳ期患者血清T3和FT3水平明显增高，CA153和hs-CRP水平明显降低（P〈0.05, P〈0.01）。结论：血清T3和FT3水平降低以及血清CA153和hs-CRP水平明显增高是乳腺癌早期诊断的良好指标，并具有治疗后随访的临床价值。Objective： To explor e the clinical value of determining serum thyroid hormone （ TH ） , CA153 and high-sensitive C-reactive protein（hs-CRP） in patients with breast cancer. Methods：The serum TH, CA153 and hs-CRP levels were determined in 156 patients with breast cancer and 60 normal controls by chemiluminescence immunoassay and immunofluorescent dry quantitative method, and which was compared. Results： Before therapy, the serum T3 and FT3 levels in 156 patients with breast cancer were significantly lower than those in 60 controls （all P〈0.01）, and decreased with severity （Ⅰ-Ⅳ stage of breast cancer）, the serum FT4 level decreased （all P〈0.05）. The serum CA153 and hs-CRP levels in 156 patients with breast cancer were significantly higher than those in 60 controls（all P〈0.01）, and increased with severity（Ⅰ-Ⅳstage of breast cancer）. In 156 patients with breast cancer after therapy, the serum T3 and FT3 levels in Ⅰstage and Ⅱstage patients with breast cancer were returned to normal levels （all P〉0.05）, the serum T3 and FT3 levels inⅢstage andⅣstage patients with breast cancer were significantly increased（P〈0.05, P〈0.01）. The serum CA153 and hs-CRP levels inⅠstage andⅡstage patients with breast cancer were returned to normal levels（all P〉0.05）, the serum CA153 and hs-CRP levels inⅢstage andⅣstage patients with breast cancer were significantly decreased（P〈0.05, P〈0.01）. Conclusion：That the serum T3 and FT3 levels decreased as well as serum CA153 and hs-CRP levels significantly increased were a good index for early diagnostic breast cancer, which has clinical value for follow-up after therapy.

关 键 词：乳腺癌 甲状腺激素 CA153 高敏C-反应蛋白 早期诊断 

分 类 号：R737.9[医药卫生—肿瘤]