不同暴露方式四溴双酚A的代谢及毒性特征  

Researches on toxicology and metabolic characteristics of tetrabromobisphenol A under different exposure ways

作　　者：高丹丹[1] 于云江[1,2] 王琼[3] 向明灯[2] 张艳平[1] 李良忠[2] 叶昊[4] 

机构地区：[1]中国环境科学研究院环境基准和风险评估国家重点实验室,北京100012 [2]环境保护部华南环境科学研究所 [3]中国疾病预防控制中心 [4]常州大学环境与安全工程学院

出　　处：《环境与健康杂志》2015年第2期165-168,共4页Journal of Environment and Health

基　　金：国家自然科学基金(21177119);环境保护部环保公益性行业科研专项(201309047)

摘　　要：四溴双酚A(TBBPA)具有高效的阻燃效率和优越的热稳定性,被广泛用于各种电子电器产品、纺织品及建筑材料等,成为世界上使用量最大的阻燃剂。该文在综述国内外相关研究的基础上,依据TBBPA的不同暴露方式总结了经口、经皮肤和经呼吸暴露TBBPA的生物体代谢特征和毒性特征。TBBPA主要是通过粪便排泄,其次为尿液;TBBPA对哺乳动物的急性毒性较小,达到g/kg体重级的剂量才能引起毒性效应;慢性毒性主要表现为内分泌干扰性、肝肾毒性、神经毒性和免疫毒性等。Tetrabromobisphenol A （TBBPA） is widely used in the field of electronic and electrical products, textiles and building materials due to its efficient flame retarded efficiency and excellent thermal stability. This paper reviewed the organism metabolism and toxicity characteristics of TBBPA by oral, inhalational and dermal exposure, and the conclusion can be summarized that TBBPA was mainly excreted through the feces, followed by urine; TBBPA can cause toxic effect when the dose of TBBPA achieved g/kg body weight level; The chronic toxicity of TBBPA was mainly manifested in the endocrine disturbance, liver and kidney toxicity, neurotoxieity and immunotoxicity.

关 键 词：四溴双酚A 代谢特征 急性毒性 慢性毒性 

分 类 号：R994.6[医药卫生—毒理学]