肾上腺髓质素与微血管密度在子宫颈癌中的表达意义研究  

Research of expression significance of adrenomedullin and microvessel density in cervical cancer

作　　者：李曼红[1] 曾庆纯[1] 

机构地区：[1]汕头大学医学院第一附属医院病理科,515041

出　　处：《中国实用医药》2015年第12期58-59,共2页China Practical Medicine

摘　　要：目的研究肾上腺髓质素(ADM)和微血管密度(MVD)在宫颈癌中的表达意义。方法选择宫颈上皮内瘤样病变患者(CIN-Ⅲ)组15例和术前无放疗、化疗史的宫颈癌(ICC)组41例,选取良性妇科疾病(NCE)而切除子宫组(NCE组)20例。采用免疫组化方法 ,检测肾上腺髓质素(ADM)阳性率以及微血管密度(MVD)情况的表达。结果 ADM阳性率及MVD的表达在NCE→CIN-Ⅲ→ICC病变组织中均呈逐渐增高的趋势,且ADM表达强度与MVD表达呈显著正相关(P<0.01)。结论 ADM在宫颈癌血管生成、侵袭和转移中起重要作用。ADM检测对进一步了解宫颈癌生物学行为和判断其预后具有一定的临床应用价值。Objective To research the expression significance of adrenomedullin and microvessel density in cervical cancer.Methods There were 15 cases in cervical intraepithelial neoplasia （CIN-Ⅲ） group, 41 cases in cervical cancer （ICC） without preoperative radiotherapy and chemotherapy, and 20 cases in benign gynecological disease （NCE） and hysterectomy group（NCE group）. Immunohistochemical method was applied to detect positive rate of adrenomedullin （ADM） and condition of microvessel density expression.Results Positive rate of adrenomedullin （ADM） and microvessel density expression were gradually increased in NCE→CIN-Ⅲ→ICC lesion tissues. Expression intensity of ADM is positively correlated with expression of MVD （P〈0.01）.Conclusion ADM plays an important role in generation, invasion and metastasis of cervical cancer. Detection of ADM can 〈br〉 provide clinical application value for understanding biological behavior and prognosis of cervical cancer.

关 键 词：宫颈癌 肾上腺髓质素 微血管密度 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]