重组人表皮生长因子联合氨磷汀治疗鼻咽癌患者放射性口腔黏膜炎的临床观察  

Clinical Observation of Recombinant Human Epidermal Growth Factor Combined with Amifostine in the Treatment of Radiation-induced Oral Mucositis in Patients with Nasopharyngeal Carcinoma

作　　者：龚倩[1,2] 谌赟 符一岚[1,2] 刘妮 付滢舟[1,2] 朱青 曹丽芝[1,2] 何奕 

机构地区：[1]湖南省肿瘤医院 [2]中南大学湘雅医学院附属肿瘤医院,长沙410013

出　　处：《中国药房》2015年第14期1971-1973,共3页China Pharmacy

摘　　要：目的：观察重组人表皮生长因子外用溶液联合注射用氨磷汀治疗鼻咽癌患者放射性口腔黏膜炎的临床效果。方法：选取2013年8月-2014年8月在我院放疗科接受治疗的96例鼻咽癌患者为研究对象,按随机数字表法分为观察组和对照组各48例。对照组于每次放疗前15~30 min静脉滴注注射用氨磷汀,200 mg/m2,10 min内滴注完毕;观察组在对照组治疗基础上,加用重组人表皮生长因子外用溶液喷洒于口腔黏膜表面。比较两组患者放射性口腔黏膜炎程度、口腔黏膜疼痛程度、NRS2002营养风险评分及营养不良风险率的差异。结果：放疗期间,观察组患者放射性口腔黏膜炎及口腔黏膜疼痛程度均轻于对照组,差异具有统计学意义（P〈0.05）。放疗结束后,观察组患者NRS2002营养风险评分及营养不良风险率均低于对照组,差异具有统计学意义（P〈0.05）。结论：重组人表皮生长因子联合氨磷汀治疗鼻咽癌放疗患者,可有效降低放射性口腔黏膜炎发生率,减轻口腔黏膜疼痛,减少营养不良风险。OBJECTIVE： To observe the clinical efficacy of recombinant human epidermal growth factor （rhEGF） combined with Amifostine for injection in the treatment of radiation-induced oral mucositis in patients with nasopharyngeal carcinoma. METH- ODS： 96 patients with nasopharyngeal carcinoma in the department of radiation oncology in our hospital from Aug. 2013 to Aug. 2014 were collected and randomly divided into observation group （n=48） and control group （n=48） by numbers. Control group was given Amifostine for injection 200 mg/m~ before 15-30 rain of radiotherapy, ivgtt, and infusion was finished within 10 min; base on the treatment of control group, observation group was added rhEGF solution for external use, spraying on the surface of the oral mucosa. The clinic data was compared, including the degree of radiation-induced oral mucositis and oral mucosa pain, NRS2002 nutritional risk scores and the risk rate of malnutrition between 2 groups. RESULTS ： During the radiotherapy, the degree of radiation-induced oral mucositis and oral mucosa pain in observation group were less than control group, with significant differ- ence （P〈0.05）. After the radiotherapy, the NRS2002 nutritional risk scores and the risk rate of malnutrition in observation group were lower than control group, with significant difference （P〈0.05）. CONCLUSIONS： The rhEGF combined with amifostine can effectively reduce the incidence of radiation-induced oral mucositis and the risk of malnutrition and relieve the oral mucosa pain in the treatment of patients with nasopharyngeal carcinoma.

关 键 词：重组人表皮生长因子外用溶液 注射用氨磷汀 鼻咽癌 放射性口腔黏膜炎 疼痛 营养不良 

分 类 号：R739.6[医药卫生—肿瘤] R781.5[医药卫生—临床医学]