缺血性脑卒中患者颈动脉狭窄程度与同型半胱氨酸相关性分析  

Correlation study of carotid artery stenosis and the degree of homocysteine in ischemic stroke patients

作　　者：焦艳[1,2] 金蓉[1,2] 张宗华[2] 赵萌[2] 崔峥[2] 

机构地区：[1]天津中医药大学研究生院,300193 [2]天津市中医药研究院附属医院功能检查科,300121

出　　处：《国际生物医学工程杂志》2015年第2期91-94,I0005,共5页International Journal of Biomedical Engineering

基　　金：天津市卫生局重点基金资助项目（2012KR19）

摘　　要：目的研究缺血性脑卒中患者同型半胱氨酸（Hcy）水平的变化，以探讨Hcy水平与颈动脉狭窄程度的相关性。方法选取颈动脉狭窄的缺血性脑卒中患者130例，依据彩色多普勒超声检测颈动脉狭窄程度的结果将其分为4组：轻度狭窄组（32例）、中度狭窄组（35例）、重度狭窄组（33例）、闭塞组（30例）。选择同期在本院的健康成年人30例为对照组。分别测定各组血浆Hcy、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）水平，并进行比较。结果缺血性脑卒中组各组与对照组TC、TG、LDL水平比较，差异均无统计学意义（P〉0．05），而血浆Hcy水平则明显高于对照组，差异有统计学意义（P〈0．05）。对照组、轻度狭窄组、中度狭窄组、重度狭窄组、闭塞组血浆Hcy水平依次升高，各组间比较差异均具有统计学意义（P〈0．05）。血浆Hcy水平与颈动脉狭窄程度之间呈正相关（r=0．835，P〈0．05），但与TC、TG、LDL水平无相关（r分别为0．031、0．012、0．018，P〉0．05）。结论Hcy与颈动脉狭窄程度有密切相关性，Hcy为缺血性脑卒中发病的危险因素。Objective To study the relationship between the stenosis content of carotid artery and the degree of homocysteine （Hcy） by analyzing the level changes of Hcy in ischemic stroke patients. Methods One hundred and thirty patients of carotid artery stenosis with ischemic stroke were divided into four groups based on the degrees of carotid artery stenosis determined by ultrasound Doppler flow imaging： the slight stcnosis group （32 patients）, the moderate group （35 patients）, the severe group （33 patients） and the total occlusion group （30 patients）. Meanwhile, 30 healthy people were chosen as the control group. The levels of serum homocysteine （Hcy）, total cholesterol （TC）, triglyceride （TG） and low density lipoprotein （LDL） of each group were measured, and the results were compared with those of the control group. Results It was found that the serum Hcy level in ischemic stroke group were significantly higher than that in the control group （P〈0.05）, whereas the variations ofTC, TG, HDL and LDL levels between the ischemic stroke group and the control group could be neglected （P〉0.05）. An obviously increased order of serum Hcy levels was observed as the following, the control group, the slight stenosis group, the moderate group, the severe group as well as the total occlusion group. The difference between every two groups was statistically significant （P〈0.05）. The level of serum Hcy was positive correlated to the content of carotid artery stenosis （r=0.835, P〈0.05）. However, no correlation was found between the carotid artery stenosis and each level of TC, TG and LDL （r= 0.031, 0.012, 0.018, respectively, P〉0.05）. Conclusions The serum Hcy level is closely related to the degree of carotid artery stenosis, and high level Hcy is suggested to be one of major risk factors for ischemic stroke.

关 键 词：彩色多普勒超声 缺血性脑卒中 颈动脉狭窄 同型半胱氨酸 

分 类 号：R743.3[医药卫生—神经病学与精神病学]