血管内皮糖萼在炎症中的作用  

Role of vascular endothelial glycocalyx in inflammation

作　　者：闫志平[1] 刘静霞[1] 刘肖珩[1] 尹红梅[1] 曾烨[1] 

机构地区：[1]四川大学华西基础医学与法医学院生物医学工程研究室,成都610041

出　　处：《国际生物医学工程杂志》2015年第2期114-118,I0007,共6页International Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目（11172189,11372203,11401253）

摘　　要：血管内皮糖萼是血管内皮细胞腔侧面的多糖蛋白复合物层。在生理状态下，其主要功能是调节血管内皮通透性及血细胞与内皮细胞间相互作用，介导血流剪切力诱导一氧化氮的释放等。炎症条件下，多种炎症介质导致血管内皮糖萼脱落，削弱了其血管保护功能；同时血管内皮糖萼的组分硫酸乙酰肝素可调控炎症发展，包括作为L-选择素的配体调节白细胞的滚动，形成趋化因子浓度梯度调节白细胞在血管腔侧面的移行及其与内皮细胞的紧密黏附，调控趋化因子由组织向血管腔的转运等。动脉粥样硬化作为一种炎症性疾病，其多种危险因子与血管内皮糖萼联系密切。综述了血管内皮糖萼在炎症和动脉粥样硬化中的作用。Luminal surface of vascular endothelium is decorated with a variety of polysaccharide-protein complexes, which constitute the glycocalyx. It has been demonstrated that vascular endothelial glycocalyx plays an impor- tant role in modulation of selective permeability of vessels, mediation of the blood cell-endothelial cell interactions and the release of nitric oxide induced by fluid shear stress under physiological condition. In inflammation condition, shed- ing of glycocalyx due to inflammation mediator leads to its functional weakening in vessel protection. At the same time, heparan sulfate as a major constituent of vascular endothelial glycocalyx could be involved in regulating the evolution of inflammation. Heparan sulfate interacts with L-selectin to mediating leukocyte rolling, presents chemokines on lumi- nal surfaces of endothelial ceils to mediate leukocyte crawling and firm adhesion, participates in transcytosis of chemokines from tissue to luminal side of endothelial cells during inflammation. Various risk factors of atherosclerosis, as an inflammatory disease, are closely associated with vascular endothelial glycocalyx. This paper is aimed to review the role of vascular endothelial glycocalyx in inflammation and atherosclerosis.

关 键 词：血管内皮糖萼 炎症 硫酸乙酰肝素 动脉粥样硬化 

分 类 号：R743[医药卫生—神经病学与精神病学] R54[医药卫生—临床医学]