脾多肽在食管癌辅助治疗的作用观察  

The role of spleen polypeptides in adjuvant treatment of esophagealcancer

作　　者：彭胜祖[1] 张云魁[1] 王彬[1] 张羽捷[1] 

机构地区：[1]山西省肿瘤医院胸外三病区,山西太原030013

出　　处：《医药前沿》2015年第4期44-45,共2页Journal of Frontiers of Medicine

摘　　要：目的：研究脾多肽注射液在食管癌患者辅助治疗的作用。方法：选择2010年10月至2014年10月间住院治疗的60例食管癌患者。随机分为观察组（在放、化疗同时联合应用脾多肽注射液）30例和对照组（单纯放化疗）30例。化疗患者均采用PF方案化疗（顺铂20mg/m2，静脉滴注1h，第1 5天；氟尿嘧啶500mg/m2，持续静脉注射24h，第1 5天；21d为1个周期）。放疗患者：放射剂量60 70Gy/30 35f/6 7w。化疗两周期或放疗结束后评价近期疗效、毒副作用、生活质量。结果：两组近期疗效相当，在胃肠道反应和肝肾功能损害方面两组无显著差异，但在骨髓抑制的发生率观察组明显低于对照组（P＜0.05），观察组患者的生活质量也优于对照组，差异有统计学意义（P＜0.05）。结论：脾多肽能明显减轻食管癌放化疗患者的骨髓抑制等毒副反应，减少放化疗中可能导致治疗中断的不良因素，明显提高放、化疗患者的生活质量，值得应用推广。ObjectiveResearch on spleen polypeptide injection the role of adjuvant therapy in patients with esophageal cancer.Methods Choose between October 2014 to October 2010 in treatment of 60 patients with esophageal cancer hospital. 30 cases were randomly divided into observation group and control group 30 cases.ResultsTwo groups of curative effect quite recently, in the aspect of gastrointestinal reaction and function of liver and kidney damage in the two groups had no significant difference, but in the incidence of bone marrow suppression group observation was lower than that in control group （P 〈 0.05）, the observation group of patients quality of life is better than control group, the difference was statistically significant （P 〈 0.05）.Conclusions Spleen polypeptides can significantly reduce esophageal radiation and chemotherapy in patients with adverse reactions such as bone marrow suppression, reduce the radiation and chemotherapy in treatment may lead to interruption of adverse factors, significantly improve the life quality of patients with radiation and chemotherapy, is worth popularizing application.

关 键 词：食管癌 脾多肽 化疗 

分 类 号：R730.5[医药卫生—肿瘤]