朗格汉斯细胞组织细胞增生症6例临床病理分析  

Clinicopathologic analysis of 6 cases with Langerhans cell histiocytosis

作　　者：邱立[1] 柳玉红[1] 温寿青 汪春福[1] 陈蕾[1] 龚静青[1] 

机构地区：[1]广东省深圳市宝安区人民医院,广东深圳518101

出　　处：《中国医药导报》2015年第14期161-163,81,共4页China Medical Herald

基　　金：广东省深圳市宝安区科技计划项目(2012015)

摘　　要：目的探讨朗格汉斯细胞组织细胞增生症(LCH)临床病理特点、免疫表型及预后特点。方法分析6例儿童LCH的临床资料及组织病理学特点,同时用免疫组化染色观察LCH的免疫表型,并结合文献复习。结果男性4例,女性2例,年龄最小23 d,最大13岁。组织学改变:受累器官内朗格汉斯细胞弥漫增生,细胞中等偏大,核呈卵圆形、肾形,可见核折叠。免疫组化:朗格汉斯细胞S-100、CD68和CD1α(+),LCA、CK、CD3、CD5、CD20(-)。结论 LCH临床表现复杂,诊断需要结合临床表现、影像学检查及组织病理学检查。该病患儿预后差别较大,取决于发病年龄、受累器官多少、器官功能受损严重性。Objective To study the clinicopathologic characteristics, immunophenotype and prognosis of Langerhans cell histiocytosis （LCH）. Methods Clinical and pathological features were studied in 6 cases of children with LCH, while the immunohistochemical staining was performed to observe the LCH immune phenotype, and combined with the literatures review. Results There were 4 males and 2 females. The youngest was 23-day-old and the oldest was 13 years. Histological changes included： diffused distribution of Langerhans cells, the cells were medium to relatively large, the nucleuses were round, oval, bean-like or folded in shape. Immunohistochemical staining showed that Langerhans cells expressed S-100, CD68 and Cdlot, but been negative for LCA, CK, CD3, CD5 and CD20. Conclusion LCH presents complex clinical symptoms. The diagnosis needs a combination of clinical features, image examination and histopathological characters. The prognosis of LCH is various, depending on the age, the number of infiltratedorgans and the function of infiltrated organs.

关 键 词：朗格汉斯组织细胞增生症 病理分析 免疫表型 

分 类 号：R733[医药卫生—肿瘤]