结直肠癌患者术前CEA、CA19-9浓度与临床病理特征及预后的关系  

Relations of preoperative CEA and CA19-9 levels with clinicopathologic profiles and prognosis in colorectal cancer patients

作　　者：钟武[1] 张磊昌[1] 钟世彪[1] 江志远[1] 陈利生[1] 

机构地区：[1]广西医科大学第一附属医院结直肠肛门外科,广西南宁530021

出　　处：《中国普通外科杂志》2015年第4期499-504,共6页China Journal of General Surgery

基　　金：国家自然科学基金资助项目(30760246);2014年广西研究生教育创新计划资助项目(YCBZ2014032)

摘　　要：目的:探讨结直肠癌患者术前CEA、CA19-9浓度与临床病理特征及预后的关系。方法:收集2007年1月—2008年7月收治并行根治性手术的356例结直肠癌患者的临床病理资料,分析血清CEA、CA19-9与临床病理特征及生存率的关系。结果:单因素分析结果显示,血清CEA浓度升高与肿瘤浸润深度、淋巴结转移、病理类型、肝转移、周围脏器受累有关(均P<0.05);血清CA19-9浓度升高与肿瘤浸润深度、腹膜转移、肝转移有关(均P<0.05)。生存分析结果显示,血清CEA浓度升高患者生存率低于血清CEA浓度正常患者(P<0.05);血清CA19-9浓度升高患者与血清CA19-9浓度正常患者生存率差异无统计学意义(P>0.05);血清CEA、CA19-9浓度同时升高患者与血清CEA升高或血清CA19-9升高患者生存率差异无统计学意义(均P>0.05),但明显低于血清CEA、CA19-9均正常患者(P<0.05)。结论:血清CEA、CA19-9浓度同时升高可能是结直肠癌的晚期事件,提示患者预后不良。Objective：To investigate the relations of CA19-9 and CEA levels with clinicopathological features and prognosis of patients with colorectal cancer.Methods：The clinicopathologic data of 356 patients with colorectal cancer undergoing radical surgery from January 2007 to July 2008 were collected.The relations of preoperative CEA and CA19-9 levels and clinicopathologic features and postoperative survival rate of the patients were analyzed.Results：Results of univariate analysis showed that the increased serum CEA level was related to depth of tumorinvasion,lymph node metastasis,histological type,liver metastases,peripheral organ involvement（all P〈0.05）.and the increased serum CA19-9 level was associated with depth of tumor invasion,peritoneal metastasis,and liver metastasis（all P〈0.05）.Results of survival analysis indicated that survival rate in patients with increased serum CEA level was lower than that in those with normal serum CEA level（P〈0.05）; survival rate had no statistical difference between patients with increased serum CA19-9 level and normal serum CA19-9 level（P〉0.05）; survival rate in patients with both increased CEA and CA19-9 levels showed no statistical dif erence compared to those with increased serum CEA or increased serum CA19-9 level（both P〉0.05）,but was signii cantly lower than in those with both normal serum CEA and CA19-9 levels（P〈0.05）.Conclusion：Simultaneously increased levels of both CEA and CA19-9 is likely related to a late-stage event in colorectal cancer,which suggests an unfavorable prognosis for the patients.

关 键 词：结直肠肿瘤 癌胚抗原 CA-19-9抗原 预后 

分 类 号：R735.3[医药卫生—肿瘤]