人乳头瘤状病毒感染与机体免疫的研究进展  

Research progress on the HPV infection and immunity

作　　者：赵静 黄浩 罗晓玲 

机构地区：[1]深圳市合一康生物科技股份有限公司,广东深圳518017

出　　处：《中国病毒病杂志》2015年第2期157-160,共4页Chinese Journal of Viral Diseases

基　　金：深圳市战略新兴产业发展专项资金(CYZZ20130329145313934)

摘　　要：人乳头瘤状病毒（human papilloma virus,HPV）是一类高度异质性的双链环状小分子DNA病毒,具有严格的嗜上皮特性,其整个生活周期都局限在上皮层,主要感染人类皮肤和黏膜,并引起相应部位上皮组织的增生性病变[1]。HPV在女性人群中感染率极高,Human papillomavirus infection has been known as the most important factor for cervical cancer.The virus exclusively infects epithelium and produces new viral particles only in fully mature epithelial cells.Most human papillomavirus infection can be cleared spontaneously by immune responses but persistent infection with high-risk human papillomavirus can cause cancer of the cervix.Up to now,many HPV therapeutic vaccines have been developed and showed excellent effects.In this review,we summarize the recent progress of HPV and immunity.

关 键 词：人乳头瘤状病毒 宫颈癌 细胞免疫 治疗性疫苗 

分 类 号：R737.33[医药卫生—肿瘤]