CD56在急性髓细胞白血病的表达及意义  

Expression and significance of CD56 in patients with acute myeloid leukemia

作　　者：范银银[1] 张宏[1] 李军[2] 朱雪明[1] 傅晋翔[2] 

机构地区：[1]苏州大学附属第二医院检验科,江苏省215004 [2]苏州大学附属第二医院血液科,江苏省215004

出　　处：《江苏医药》2015年第8期895-898,共4页Jiangsu Medical Journal

摘　　要：目的探讨CD56在急性髓细胞白血病(AML)患者中的表达及意义。方法采用多色流式细胞术对102例初诊AML的患者进行免疫表型检测,分析CD56在AML患者中的表达及其与其他分化抗原的相关性。结果 102例AML患者中,23例(22.5%)表达CD56。伴有淋系抗原表达的AML(Ly+AML)组CD56表达率高于Ly-AML组(χ2=9.54,P<0.01),Pearson相关性分析显示,CD56的表达与伴淋系抗原的表达呈正相关(r=0.304,P<0.05),而与年龄、性别、CD7、CD34、CD117及人类白细胞抗原DR的表达无明显相关性。CD56+AML组的完全缓解(CR)率低于CD56-AML组(42.1%vs.74.5%)(χ2=6.91,P<0.05)。多因素Logistic回归分析显示,CD56是影响AML患者CR率的独立危险因素(P<0.05)。CD56+AML的无病生存期(DFS)较CD56-AML短(χ2=18.97,P<0.01)。COX回归多因素分析结果提示,CD56是影响AML患者DFS的独立危险因素(P<0.01)。结论 CD56+AML患者CR率明显降低,DFS明显缩短,预后较差。CD56可作为评估AML患者预后的指标。Objective To investigate the expression and significance of CD56 in the patients with acute myeloid leukemia （AML） .Methods The immunophenotype was detected by multi-color flow cytometry in 102 AML patients .The expression of CD56 and its correlation with other leukocyte differentiation antigens were analyzed .Results Of 102 AML patients ,CD56 expression was found in 23（22.5% ） cases .The expression of CD56 was positively correlated with lymphoid antigen expression （r=0 .304 ,P〈0 .05） ,but had no significant correlation with sex ,age ,and the expressions of CD7 , CD34 ,CD117 and HLA-DR .The complete remission（CR） rate of the patients with CD56＋ AML was significantly lower than that of those with CD56^- AML （42.1% vs .74.5% ）（χ^2 =6 .91 ,P〈0 .05） . Logistic multivariate regression analysis showed that CD 56 was an independent factor for CR rate of AML patients（P〈0 .05） .Survival analysis showed that disease-free survival（DFS） of patients with CD56^＋ AML was shorter than that of those with CD56^- AML （χ^2 =18 .97 ,P〈0 .01 ） .COX regression multivariate analysis demonstrated that CD56 was an independent factor for DFS of AML patients（P〈0 .01） .Conclusion The expression of CD56 in AML patients indicates a poor prognosis with a lower CR rate and a shorter DFS .CD56 may be taken as an independent prognostic factor in AML patients .

关 键 词：急性髓细胞白血病 CD56 

分 类 号：R733[医药卫生—肿瘤]